Identifying the genetic basis of complex traits remains an important and challenging problem with the potential to affect a broad range of biological endeavors. A number of statistical methods are available for mapping quantitative trait loci (QTL), but their application to high-throughput phenotypes has been limited as most require user input and interaction. Recently, methods have been develo...

body weight (bw) and carcass traits are complex and important economic traits that may benefit from the implementation of mas. the objective of the current study was to identify qtl associated with bw and carcass traits in an experimental half-sib cross of japanese quails selected for bw at 4 weeks of age. body weight and carcass traits were measured in the f2 population. total f2 individuals a...

Epistasis, i.e., the fact that gene effects depend on the genetic background, is a direct consequence of the complexity of genetic architectures. Despite this, most of the models used in evolutionary and quantitative genetics pay scant attention to genetic interactions. For instance, the traditional decomposition of genetic effects models epistasis as noise around the evolutionarily-relevant ad...

Although the interval mapping method is widely used for mapping quantitative trait loci (QTLs), it is not very well suited for mapping multiple QTLs. Here, we present the results of a computer simulation to study the application of exact and approximate models for multiple QTLs. In particular, we focus on an automatic two-stage procedure in which in the first stage “important” markers are selec...

Some diseases, such as cystic fibrosis and Huntington’s disease, are the result of a change in a single gene. No single gene is responsible for alcohol abuse and dependence, however. Many genes that play roles in a variety of normal human behaviors and sensory perception are involved. Research has not yet pinpointed specific genes that “predispose” a person to alcohol abuse or dependence. Once ...

Alcoholism is a quantitative disorder that is caused by the combined influences of numerous genes (i.e., quantitative trait loci [QTLs]) and environmental factors. To identify QTLs for alcoholism, researchers compare subject groups (e.g., inbred mouse strains) that differ in both their genetic makeup (i.e., genotype) and alcohol-related trait (e.g., sensitivity to certain alcohol effects). Usin...

With the increasing number of polymorphic markers identified on the genetic map, positional cloning has become an extremely powerful tool, permitting the linkage and identification of a large number of disease genes. As the human genome project pro­ gresses and the gene map becomes as dense as the microsatellite polymorphism map, scientists will identify more disease genes through a combination...

pod length is one of the effective components on canola yield selection on the basis of which can increase not only the seed yield but also the oil yield. molecular markers asso-ciated with long pod loci were identified in a doubled haploid population derived from a cross between the canola lines ‘quantum’ (long pod) ‘china a’ (short pod) using rapd and bulked segregant analysis. a molecular ma...