abstractintroduction: parkinson's disease (pd) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. therefore, its neuroprotective effect in a model of parkinson’s disease in rat was evaluated.meth...

Fruits of sweet orange (Citrus sinensis), a popular commercial Citrus species, contain high concentrations of flavonoids beneficial to human health. These fruits predominantly accumulate O-glycosylated flavonoids, in which the disaccharides [neohesperidose (rhamnosyl-α-1,2-glucose) or rutinose (rhamnosyl-α-1,6-glucose)] are linked to the flavonoid aglycones through the 3- or 7-hydroxyl sites. T...

Quercetin Protects DNA from Oxidative Damage in Diabetics Diabetics have reduced antioxidant defenses and an increased risk for free-radical mediated conditions such as heart disease and retinopathy. Quercetin, a dietary flavonoid with antioxidant properties, has been shown to protect retinal pigment epithelial and cortical cells during oxidative stress in vitro1, and to inhibit tyrosine kinase...

Experimental evidence documents that nutritional phytoestrogens may interact with reproductive functions but the exact mechanism of action is still controversial. Since quercetin is one of the main flavonoids in livestock nutrition, we evaluated its possible effects on cultured swine granulosa cell proliferation, steroidogenesis, and redox status. Moreover, since angiogenesis is essential for f...

Most flavonoids exist as sugar conjugates. Naturally occurring flavonoid sugar conjugates include glucose, galactose, glucuronide, rhamnose, xylose, and arabinose. These flavonoid glycosides have diverse physiological activities, depending on the type of sugar attached. To synthesize an unnatural flavonoid glycoside, Actinobacillus actinomycetemcomitans gene tll (encoding dTDP-6-deoxy-L-lyxo-4-...

Background: Flavonoids are effective antioxidants and may protect against several chronic diseases. Objective: The association between flavonoid intake and risk of several chronic diseases was studied. Design: The total dietary intakes of 10 054 men and women during the year preceding the baseline examination were determined with a dietary history method. Flavonoid intakes were estimated, mainl...

The bioactive ethyl acetate and N-butanol soluble parts of an ethan leaves was subjected to column chromatography over silica gel G (60 120 flavonoid rich fraction over sephadex LH-20 eluted with methanol led to th identified as quercetin 3-O-α-arabinoside (I), quercetin(II) and quercetin 3elucidated by H and C-NMR data and are reported here for the first time

Plants produce two flavonoid O-pentoses, flavonoid O-xyloside and flavonoid O-arabinoside. However, analyzing their biological properties is difficult because flavonoids are not naturally produced in sufficient quantities. In this study, Escherichia coli was used to synthesize the plant-specific flavonoid O-pentosides quercetin 3-O-xyloside and quercetin 3-O-arabinoside. Two strategies were use...

Bryophytes are the second largest group in the plant kingdom, but studies conducted to better understand their chemical composition are limited and scattered. Axenically grown bryophytes expressed potential in biotechnological processes. The present study was designed to investigate the in vitro cell growth, culture parameters and their effect on flavonoid synthesis. Chlorophyll-containing call...