The discovery of quorum sensing in Proteobacteria and its function in regulating virulence determinants makes it an attractive alternative towards attenuation of bacterial pathogens. In this study, crude extracts of Phyllanthus amarus Schumach. & Thonn, a traditional Chinese herb, were screened for their anti-quorum sensing properties through a series of bioassays. Only the methanolic extract o...

Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lo...

Standardized extract of Phyllanthus amarus has previously been shown to have a strong inhibitory effect on phagocytic activity of human neutrophils. The current study was carried out to evaluate the effects of constituents of the extract of P. amarus on nitric oxide (NO) production as well as lymphocyte proliferation and cytokine release from phagocytes. Three compounds, ethyl 8-hydroxy-8-methy...

The antimicrobial efficiency of Phyllanthus amarus Schum. and Thonn, medicinal plants (leaf extracts), was examined using ethanol and chloroform as solvents and tested against human pathogens ; Staphylococcus aureus, Escherichia coli, and Candida albican, using the agar well-diffusion method and minimum inhibitory concentration. The result of the phytochemical analysis of the plant showed that ...

Herbs have always formed an integral part of human health and are used in the treatment of several human diseases. One of such species which have wide patronage of use is Phyllanthus amarus. This herb is in traditional medicine for more than 3,000 years. The plant has also served as lead for several experimental investigations that explored its phytochemical constituents and pharmacological use...

AIM The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats. MATERIALS AND METHODS Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extrac...

The effects of the methanol extracts of the leaves of Phyllanthus amarus on the sperm parameters of male Guinea pigs were investigated. The effects of Vitamin E on the sperm parameters were also investigated and compared to that of Phyllanthus amarus. The phytochemical screening of the leaves of Phyllanthus amarus was also carried out. The methanol extract of the Phyllanthus amarus leaf (50-200...

BACKGROUND Methylglyoxal (MG) is one of the most reactive glycating agents, which result the formation of advanced glycation end-products (AGEs) that have been implicated in the progression of age-related diseases. Inhibition of MG-induced AGE formation is the imperative approach for alleviating diabetic complications. The objective of this study was to investigate the MG-trapping abilities of ...

The standardized methanol extracts of Phyllanthus amarus and P. urinaria, collected from Malaysia and Indonesia, and their isolated chemical markers, phyllanthin and hypophyllanthin, were evaluated for their effects on the chemotaxis, phagocytosis and chemiluminescence of human phagocytes. All the plant extracts strongly inhibited the migration of polymorphonuclear leukocytes (PMNs) with the Ma...