Radiation optic neuropathy is a devastating form of vision loss that can occur months to years after radiation therapy for tumors and other lesions located in close proximity to the visual pathways. We present the case of a 24-year-old woman who underwent external beam radiation for treatment of a tectal pilocytic astrocytoma, and 5 years later she developed bilateral radiation optic neuropathy...

For diagnosing radiation optic neuropathy (RON) ophthalmological and imaging data were evaluated from 63 acromegalic patients, irradiated between 1967 and 1998. Two patients developed RON: one patient in one optic nerve 10 years and another patient in both optic nerves 5 months after radiation therapy. RON is a rare complication after external beam radiation therapy for acromegaly, which can oc...

background: the effects of high dose steroids for the treatment of methanol optic neuropathy was evaluated in this study. methods: in an interventional case series, 9 patients with a history of sudden visual loss after an ingestion of homemade alcoholic beverages were included in the study. the patients received 250 mg intravenous methyl prednisolone every 6 hours for 4 days continued with oral...

Purpose To report a case of optic neuropathy and retinopathy from a dose of radiation traditionally thought to be safe to the visual system and discuss strategies for preventing vision loss when using radiation to treat intraocular tumors. Observations A 44-year-old woman presented with new, painless vision loss in the left eye eighteen months after receiving proton beam radiotherapy (20 Gy d...

purpose: to compare the effect of high dose intravenous corticosteroid therapy with placebo in the treatment of recent traumatic optic neuropathy (ton). methods: in a double masked-placebo controlled clinical trial, 31 eyes of 31 patients were randomly assigned into two groups. only patients with history of ophthalmic or head trauma within the past 7 days were included. unconscious patients, th...

conclusions although toxoplasmosis nr is rare, it should be considered in the differential diagnoses of nr. case presentation a 13-year-old girl presented with painless subacute visual loss in her right eye for a week at khatam-al-anbia eye hospital in mashhad, iran. following comprehensive evaluation, a diagnosis of toxoplasmic nr was made. the nr favorably responded to classic anti-toxoplasmo...

PURPOSE Patients with Leber hereditary optic neuropathy (LHON) and cone-rod dystrophy (CRD) have central vision loss; but CRD damages the retinal photoreceptor layer, and LHON damages the retinal ganglion cell (RGC) layer. Using diffusion MRI, we measured how these two types of retinal damage affect the optic tract (ganglion cell axons) and optic radiation (geniculo-striate axons). METHODS Ad...

Perhaps because of its innate, precarious blood supply, clinical experience has shown that the anterior visual pathways are especially sensitive to high doses of ionizing radiation. As a result, the risk of radiation injury to the optic nerves has engendered considerable angst in the setting of stereotactic radiosurgery (SRS). The general consensus has been that the likelihood of complications ...