hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. recent research has increased our understanding of this pathway and its relation to other signalling pathways. in addition, a large number of studies confirmed the alterati...

objective: the objective of this study is to develop and assess targeted pamam-peg nanocarrier with anti-tag72 nanobody for t-bid gene coding construct delivery into the human colonic adenocarcinoma cells. materials and methods: nanobody (nb) coding sequence was subcloned into psj expression vector for large-scale production and then nb was purified by ni++ affinity chromatography. sds-page an...

background: the fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.the high linear energy transfer (let) of alpha radiation to the targeted cancer cellscauses double strand breaks in dna. at the same time, the short range radiation spares adjacent normal tissues. this targeted approach complements conventional external beam radiotherapy and ch...

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

production and approval of trastuzumab (herceptin®) for the treatment of metastatic breast cancer (mbc) was a millstone in antibody-based targeted therapy in the cancer treatment. however, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. the majority of patients who benefit from the drug acqui...

The 2013 St. Gallen Consensus Conference on early breast cancer provided mostly evidence-based, globally valid treatment recommendations for breast cancer care, with a broad spectrum of acceptable clinical practice. This report summarizes the results of the 2013 international panel voting procedures with regard to loco-regional and endocrine treatment, chemotherapy, targeted therapy as well as ...

An efficient cancer treatment means to restore controlled tissue growth via interfering with cell signalling pathways regulating cell-cycle and apoptosis. Among many treatment strategies, targeted cancer therapy and radiation play a pivotal role. Since cancer is one of the leading causes of death worldwide, it is reasonable to invest time and resources in the enlightening of mechanisms, which u...

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Surgery offers the only hope for cure. However, the potentially curable method is only possible for a small proportion of those afflicted, for the rest, palliative treatment is indicated. Despite all the treatment options when used as monotherapy, patients with HCC have a poor long term prognosis. In this setting, mult...