Objective: Technetium-99m-sestamibi (-1"'Tc-MIBI) is a radiopharmaceutical imaging agent useful for assessing myocardial perfusion. We present a simple, rapid and accurate SepPak® method to confirm the radiochemical purity of "'Tc-MIBI. Methods: Technetium-99m-MIBI preparations of high (>95%), intermediate (83-90%) and low (25-43%) radiochemical purity were evaluated by the recommended thinlaye...

The present paper is concerned with radiochemical methodology to furnish the trifluoromethyl motif labelled with (18)F. Literature spanning the last four decades is comprehensively reviewed and radiochemical yields and specific activities are discussed.

Because radiopharmaceuticals are intended for human administration, quality control procedures are essential in ensuring the safety of these preparations. Although extensive quality control procedures are performed by the manufacturer, many radiopharmaceutical preparations are prepared in nuclear medicine departments using kits and short-lived radionuclides including technetium-99m CmTc) and in...

The preparation of N-succinimidyl-4-[131I]iodobenzoate (SIB) has been optimized using an alternative technique employing Cu(I)-assisted radioiododebromination that produces p-[131I]iodobenzoic acid. The reaction conditions were optimized and radiochemical purity of more than 90% was obtained when using 160 degrees C, 60 min reaction time and a [CuCl]/[p-bromobenzoic acid] relation of about 10(-...