e welcome the interest of Drs. Rapezzi and colleagues in our rticle (1). We did not discuss radionuclide imaging of amyloid ith tracers developed for bone scintigraphy because few data are vailable and because of constraints of space. Bone scintigraphy in myloidosis has been evaluated systematically only in very small eries (2), and there is no evidence as yet for a specific molecular nteractio...

introduction: the purpose of the present study was to evaluate the effect of prednisolone on the sensitivity of bone scanning to detect the simulated closed fracture in the rat tibia.  methods: a total number of forty eight adult, male nmri rats randomly assigned into two parts, one part for 4 and other for 8 weeks experiments. each part has been divided into four groups, one group not receivi...

It is well established that Technetiummethylene diphosphonate (Tc MDP) whole body bone scintigraphy (WBBS) can demonstrate multiple lesions with increased radiotracer concentration in involved bone. But it is hard to differentiate multiple benign osteolytic lesions from disseminated bone metastases. Even combined with medical history and multiple imaging results, clinical diagnosis of metastati...

Bone scintigraphy is a very sensitive method for the detection of osteoblastic activity of the skeleton. The technique consists of imaging the uptake of bone-seeking radiopharmaceuticals, particularly technetium-99m labeled diphosphonates, in the mineral component of bone, which consists of hydroxyapatite crystals and calcium phosphate, as well as in the organic matrix such as collagen fibers. ...

Although a true fracture is commonly associated with increased radionuclide uptake on bone scintigraphy, it is also possible for an area with no increased uptake (a cold line) to indicate fracture, as demonstrated in this case study. Detection of an occult acute hip fracture through recognition of a cold fracture line is important because of the associated therapeutic, economic, and medicolegal...

Radionuclide imaging is a non-invasive modality based on tracer physiology widely utilized in the diagnosis, staging, therapeutic evaluation, and monitoring of metastatic disease spectrum malignancies. Calcific tendinopathy well-recognized disorder related to deposition calcium hydroxyapatite crystals within tendons. We describe patient with urothelial carcinoma bladder revealing increased upta...

Bone and soft tissue disease is kind of detrimental disease and the precise diagnosis and timely therapy is also the clinical doctors’ object of a prolonged endeavour. This chapter will introduce the diagnostic and therapeutic methods of bone and soft tissue diseases with nuclear medicine techniques. The singular advantages of skeletal scintigraphy are high sensitivity in detecting early diseas...

Radionuclide bone scanning has been a mainstay in the noninvasive evaluation of bone disease for decades. While SPECT imaging provides better evaluation of abnormal tracer uptake than planar scintigraphy, it still produces less than ideal anatomic localization. The introduction of hybrid SPECT/CT devices such as BrightView XCT has added value in improved localization of skeletal lesions and imp...