The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating the efficacy of combining radioprotective agents developed for administration prior to irradiation and therapeutic agents administered in a post-irra...

Singleand double-stranded (RF) DNA of page <?X-174 were 60Co-gamma irradiated. Depen­ dence of radiosensitivity on the concentration of cysteamine and cystamine was measured. Radio­ resistance of DNA in vivo (phage particles) as well as of DNA in vitro (infectious DNA) increase between 10-4 and 10—1 M of superprotective agents. The same relationship is observed when the DNA is in the dry and in...

In this brief communication, we describe the existence o f a pulmonary polyamine uptake system. We discuss the presence o f similar uptake systems in a numbcr o f other cell typcs. in particular certain tumour cells. Finally, we discuss the possible therapeutic exploitation of this pulmonary polyaminc uptake system. in particular, in relation to the design of novel anticancer agents and better ...

EMETIC AND ANTIEMETIC DRUGS 4.1. Neuroleptics 4.1.1. Phenothiazines 4.1.2. Butyrophenones and Related Compounds 4.1.3. Substituted Benzamides; Metoclopramide. Sulpiride and Others 4.2. Antihistamines 4.3. Miscellaneous Antiemetic Drugs 4.3.1. 4.3.2. 4.3.3. 4.3.4. 4.3.5. 4.3.6. 4.3.7. 4.3.8. 4.3.9. 4.3.10. Cannabinoids Steroids Domperidone Anxiolytics and Sedatives Analgesics Tricyclic Antidepre...

Background: Synthetic radio-protective agents like aminothiols are toxic and FDA approved agent amifostine is no exception. Some Ayurvedic herbs have shown radioprotective potential. This study was carried out to test and compare the radioprotective potential of Curcuma longa (CL) Tinospora cordifolia (TC), Zizyphus mauritiana (ZM) and Ocimum sanctum (OS) against 2Gy gamma irradiation ...

background: synthetic radio-protective agents like aminothiols are toxic and fda approved agent amifostine is no exception. some ayurvedic herbs have shown radioprotective potential. this study was carried out to test and compare the radioprotective potential of curcuma longa (cl) tinospora cordifolia (tc), zizyphus mauritiana (zm) and ocimum sanctum (os) against 2gy gamma irradiation in swiss ...