Purpose: Radium-223 dichloride (radium-223, Xofigo), a targeted alpha therapy, is currently used for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastases. This study examines the mode-of-action and antitumor efficacy of radium-223 in two prostate cancer xenograft models.Experimental Design: Mice bearing intratibial LNCaP or LuCaP 58 tumors were randomi...

The oxi-hydroxides, present at trace level in uranium mill tailings, are responsible of about 70% of the 226 radium sorption, half being fixed on crystallized forms. This radionuclide (half time = 1622y), present at high level (50 to 100kBq.kg), can be released in groundwater, involving a possible contamination of the food chain (actual concentration limit = 0.37Bq.l). So, it is very important ...

This little volume deals briefly and completely with the properties of radium both from a therapeutic and physical point of view. Briefly dealing with the observations on the various phenomena which lead to the discovery of radium itself, the author passes to the physical properties of the element, and goes into the differentiation between the alpha, beta and gamma rays. The relationship existi...

publication of an up-to-date manual in a concise and convenient form, which should be in the hands of every practitioner. The more widely such knowledge is spread amongst the profession, the sooner will the day arrive when public opinion backed by the medical profession will demand a radium-institute in this country. Until that day arrives practitioners can only equip themselves to advise their...

BACKGROUND In Alpharadin in Symptomatic Prostate Cancer (ALSYMPCA) trial, radium-223 versus placebo prolonged overall survival with favorable safety in castration-resistant prostate cancer patients with symptomatic bone metastases. Long-term radium-223 monitoring underlies a comprehensive safety and risk/benefit assessment. OBJECTIVE To report updated ALSYMPCA safety, including long-term safe...

A Python program is presented to expedite the process of correcting raw data and propagating related uncertainties from Radium Delayed Coincidence Counting (RaDeCC) instruments. The performance was validated against an established method with real data. Excellent agreement between determinations excess radium-223, actinium-227, radium-224, thorium-228 radium-226 achieved, minor discrepancies in...

Of all the scientific discoveries of the last year one stands pre-eminent, not only from its scientific importance, but als? from the great public interest it has excited. I refer to discovery by Mons. and Madame Curie of radium. Thl5 discovery was not like that of the Rontgen rays suddenly, but had been led up to by the researches 0 Becquerel and of Rontgen, and was ultimately due to ^e painst...

Two important facts have drawn the attention of medical men to radio-activity. The first fact was the observation that radium rays affect the tissues of the human bod}\ For ljke Ronto-enrays they are able to cause serious injuries to&the skin. The first man who tried to utilise radium rays for medical purposes was Dr. Danlas of the St. Louis Hospital in Paris, who used them successfully to cure...

Background Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established. Patients and methods The radium-223 ALSYMPCA trial enrolled patients with CRPC and symptomatic bone metastases. Prognostic potential of ...

Becquerell has observed that p-rays change yellow phosphorus into red form. Ramsey* and Cameron* have shown that the radium emanation has destruotive and partial synthetic actions upon water, carbon monoxide, carbon dioxide, hydrogen chloride, and ammonia. The decomposing action of radium rays on the lecithin molecule has been observed by Schwara,4 Schaper,& and Werner.6 On the other hand, no s...