Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-inte...

Reclaimed asphalt pavement (RAP) is one of the waste materials that highway agencies promote to use in new construction or rehabilitation of highways pavement. Since the use of RAP can affect the resilient modulus and other structural properties of flexible pavement layers, this paper aims to employ two different artificial neural network (ANN) models for modeling and evaluating the effects of ...

To RSVP or for more information, please call Daniel Leonardich at 415.734.2080 or email [email protected] Science for Life lectures are free with open seating. Parking is available across the street in the UCSF Rutter Center garage. Co-sponsored by San Francisco Conservatory of Music cellist Erin Wang will share with us a brief discussion of “evolution” from baroque through contempora...

Introduction Cartilage-derived retinoic acid-sensitive protein (CDRAP) is a 11-kDa protein and isolated from bovine articular chondrocytes and human melanoma cell lines (melanoma inhibitory activity or MIA). In normal tissue, it is expressed specifically in cartilage cells, but in tumors it has been shown to be expressed in melanoma, chondrosarcoma, and breast cancer to date. CD-RAP/MIA is expr...

In this paper, a random access preamble (RAP) design technique for underwater acoustic cellular systems is proposed. After showing that the conventional RAP used in long term evolution (LTE) systems is not appropriate for underwater acoustic cellular systems, two different types of RAPs (RAP 1 and RAP 2) are proposed to detect the identity of underwater equipment/nodes (UEs) and estimate the ti...

Abstract Effective immunotherapy for glioma has not yet been established. We have found the energy metabolic status of immune cells within tumor microenvironment is remarkably different between intracerebral and extracranial tumors. In mice bearing SB28-EGFRvIII gliomas with intravenous infusion EGFR vIII-targeting CAR-T cells, we that mitochondrial markers in tumor-infiltrating T were down-reg...

Recent advances in molecular biology have enabled the genotyping of individual nematodes, facilitating the analysis of genetic variability within and among plant-pathogenic nematode isolates. This review first describes representative examples of how RFLP, RAPD, AFLP, and DNA sequence analysis have been employed to describe populations of several phytonematodes, including the pinewood, burrowin...

N-RAP, a muscle-specific protein concentrated at myotendinous junctions in skeletal muscle and intercalated disks in cardiac muscle, has been implicated in myofibril assembly. To discover more about the role of N-RAP in myofibril assembly, we used the yeast two-hybrid system to screen a mouse skeletal muscle cDNA library for proteins capable of binding N-RAP in a eukaryotic cell. From yeast two...