Background: Parkinson’s disease is the second major neurodegenerative diseases secondarily to Alzheimer’s disease. Rapamycin a fermentation product, which derived from Streptomyces hygroscopius. The aim of this study investigate effect rapamycin and its potential mechanisms on acute attack 1-methyl-4-phenyl-1,2,3,6-four hydrogen pyridine (MPTP) induced (PD) in mice.

Background: Management of multiple sclerosis (MS) is based on the usage of immunosuppressive and immune-modulating medications. Cytokines play an important role in the pathogenesis of MS. Objective: To evaluate the effects of rapamycin on the concentrations of Th1/Th2/Th17 serum cytokines in patients with MS. Methods: Six patients with relapsing remitting MS as a case group and 6 healthy indivi...

introduction: multiple sclerosis (ms) is generally known as a manageable but not yet curable autoimmune disease affecting central nervous system. a potential therapeutic approach should possess several properties: prevent immune system from damaging the brain and spinal cord, promote differentiation of oligodendrocyte progenitor cells (opcs) into mature oligodendrocytes to produce myelin, preve...

Abstract Background Knowledge with respect to regulatory systems for cellulase production is prerequisite exploitation of such networks increase production, improve fermentation efficiency and reduce the relevant cost. The target rapamycin (TOR) signaling pathway considered as a central hub coordinating eukaryotic cell growth metabolism environmental inputs. However, how what extent TOR are inv...

background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...

background: pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. breast cancer is one of the most common cancers among women worldwide. treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...

In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the block induced by Mycobacterium tuberculosis (Mtb) promotes a Th1 response via IL-12 secretion. Here, immunostimulatory activity of rapamycin in Mtb-infected DC was further investigated analyzing both transcriptome translatome gene profiles. Hundreds differentially expressed genes (...

silybum marianum, is known to have anti-inflammatory, hepatoprotective and anticarciogenic effects. the aim of this study was to compare effects of silymarin, rapamycin and fk506 on proliferation and apoptosis of human t cells stimulated with con a. peripheral blood mononuclear cells (pbmc) were stimulated with concavalin a  ( con a) (5µg/ml) and then treated with different inhibitors (silymari...

Over the past decades, natural polysaccharides have received considerable attention to developing nano-drug delivery systems for of anticancer drugs. However, low solubility these agents within biological fluid has reduced their efficacy in inhibiting growth cancer cells. In this study, self-assembled cationic based on dextran-stearic acid-spermine conjugates (D-SASp) were synthesized, and pote...