Abstract* Introduction: Chronic morphine exposure can cause addiction and affect synaptic plasticity, but the underlying neural mechanisms of this phenomenon remain unknown. Herein we used electrophysiologic approaches in hippocampal CA1 area to examine the effect of chronic morphine administration on short-term plasticity. Methods: Experiments were carried out on hippocampal slices taken f...

In this paper, ratcheting behavior of beams subjected to mechanical cyclic loads at elevated temperature, using the rate dependent Chaboche unified viscoplastic model with combined kinematic and isotropic hardening theory of plasticity, is investigated. A precise and general numerical scheme, using the incremental method of solution, is developed to obtain the cyclic inelastic creep and plastic...

Predicting the behavior of complex systems is one main goals science. An important example plastic deformation micron-scale crystals, a process mediated by collective dynamics dislocations, manifested as broadly distributed strain bursts and significant sample-to-sample variations in response to applied loading. Here, combining large-scale discrete dislocation simulations machine learning, we s...

Theoretical and computational frameworks for synaptic plasticity and learning have a long and cherished history, with few parallels within the well-established literature for plasticity of voltage-gated ion channels. In this study, we derive rules for plasticity in the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, and assess the synergy between synaptic and HCN channel pla...

Plasticity in solids is dependent on microstructural history, temperature, and loading rate, sample-dependent knowledge of yield points structural materials adds reliability to mechanical behavior. Yielding commonly measured through controlled testing, ways that either distinguish elastic (stress) from total deformation measurements or identify plastic slip contributions. In this paper, we show...

Long-term potentiation (LTP) is a form of activity-dependent plasticity that occurs during learning. Potassium channels are the most diverse group of all ion channels that related to synaptic plasticity. Small-conductance calcium-activated potassium channels (SKs) are found in hippocampal CA1 neurons and by inhibiting of postsynaptic potentials are involved in synaptic transmission impairment. ...