The RD12 TTCmi provides a standard interface between the LHC machine timing which is broadcast from the Prevessin Control Room (PCR) and the TTC distribution systems of the individual LHC experiments. The TTCmi consists of a minicrate (see Fig. 1) containing a number of modules which are configured to suit the requirements of the TTC system of the LHC experiment. The modules are interconnected ...

tuberculosis (tb) is one of the most important aids associated infectious diseases worldwide. it is a leading cause of illness and death among people with hiv/aids in resource-poor areas of the world. the annual incidence of tb among indigenous iranians stands at 14 cases per 100,000 inhabitants. this study aimed to identify mycobacterium infection among iranian hiv positive patients. two sputu...

Differentiation of members of the Mycobacterium tuberculosis complex by conventional mycobacteriological methods is time consuming, making surveillance of species-specific disease difficult. A two-step, multiplex polymerase chain reaction (PCR) method based on genomic regions of difference (RD1, RD1(mic), RD2(seal), RD4, RD9 and RD12) was developed for the differentiation of M. canettii, M. tub...

The funding statement presented in [1] is incomplete. The correction is as follows: ‘This work was supported by predoctoral fellowship FI05/00569 to A.C. and by Plan Nacional de IþDþi and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economı́a y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD12/001...

Retinitis pigmentosa (RP) is one of the leading causes of adult blindness and has no established therapy. We have shown that valosin-containing protein (VCP) modulators, Kyoto University Substances (KUSs), ameliorated abnormally low ATP levels by inhibiting the ATPase of VCP, thereby protected several types of cells, including retinal neurons, from cell death-inducing insults. In this study, we...

Comparative genomic studies have identified 11 regions of difference (RD1, RD4, RD5, RD6, RD7, RD9, RD10, RD11, RD12, RD13 and RD15) in Mycobacterium tuberculosis genome which are absent in all vaccine strains ofM. bovis BCG. The proteins encoded by genes predicted in these RDs could be useful as protective vaccines and/or exacerbate the disease process by inducing cellular immune responses inv...

1BCNatal Barcelona Center for Maternal-Fetal Medicine and Neonatology (Hospital Sant Joan de Deu and Hospital Clinic), Barcelona, Spain 2Department of Pathology, Hospital Sant Joan de Deu, Barcelona, Spain 3Maternal and Child Health and Development Network II (SAMID II) RD12/0026, Institute of Health Carlos III, Madrid, Spain *Corresponding author Maria Dolores Gómez Roig, MD, PhD Hospital Sant...

PURPOSE Dramatic restoration of retinal function has followed subretinal viral-mediated gene therapy in RPE65-deficient animal models of human Leber congenital amaurosis (LCA) caused by RPE65 mutations. Progress in early-phase clinical trials of RPE65-LCA prompted us to begin development of an in vivo bioassay of clinical grade vector stability for later-phase trials. METHODS Naturally-occurr...