abstract- the syndrome of diabetes mellitus, sensorineural deafness and megaloblastic anemia dose not result from thiamine deficiency. the previous reported patients had no sign of beriberi, had normal nutrition, and had no evidence of malabsorption. the features of this syndrome with apparent inheritance of autosomal recessive trait may define this puzzling syndrome as a true thiamine dependen...

background: tramadol, an analgesic drug abused by opioid addicts, is also abused accidentally or for suicidal purposes. tramadol poisoning can induce cns depression, seizures, coma, and ultimately death. case: in this report, a 30-year-old male was admitted to the emergency department due to suicidal attempt with ingestion of 14000 mg (140 tablet 100 mg) of tramadol. he had history of suicidal ...

During atrial fibrillation (AF), the atrioventricular (AV) node is continuously bombarded with atrial impulses. The AV nodal properties, and in particular the refractoriness, play an important role in determining the ventricular response during AF. Therefore, it is very useful to determine the refractory period of the AV node non-invasively. The lower envelope of the Poincarè plot (a plot repre...

how to cite this article: mollamohammadi m, tonekaboni sh, pirzadeh z, vahedian m . pregabalin in childhood epilepsy: a clinical trialiran j child neurol. 2014 autumn;8(4): 62-65. abstract objective the prevalence of active epilepsy is about 0.5–1%, and approximately 70% of patients are cured with first anti-epileptic drugs and the remaining patients need multiple drugs. pregabalin as an add-on...

Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we repo...

introduction: refractory status epilepticus is a life-threatening disease in children wherein seizure movements don't response to first line anti convulsion drugs. this study reviewed risk factors, management and early outcome of children with refractory status epilepticus. methods: patients with refractory status epilepticus admitted in tabriz children's hospital between 2003 and 200...

lamotrigine (ltg), a newly developed antiepileptic drug (aed), is efficacious in treating refractory epilepsy. this study was designed to evaluate the efficacy and safety of ltg as add-on therapy in 40 children with refractory epilepsy. the trial was an open-labeled prospective study in children with drug-resistant epilepsy aged <14 years, who had at least 4 seizures per month in spite of recei...