Numerous studies have investigated utility of esophageal intraluminal baseline impedance levels (BILs) in gastroesophageal reflux disease (GERD). However, effect of BILs in refractory GERD (RGERD) has not been well investigated. The aim of this study is to evaluate role of BILs in RGERD patients. Total 62 subjects with refractory gastroesophageal reflux symptoms underwent 24-hour impedance-pH m...

Up to 40% of patients with gastroesophageal reflux disease (GERD) suffer from proton pump inhibitor refractory GERD but clinically the medications to strengthen the OPEN ACCESS Molecules 2015, 2

We investigated the effects of rikkunshito, in combination with a proton pump inhibitor, on symptoms and quality of life in patients with proton pump inhibitor-refractory gastroesophageal reflux disease. The subjects were 47 patients with gastroesophageal reflux disease with residual symptoms such as heartburn following 8 weeks of proton pump inhibitor therapy. We administered these subjects ri...

results in total, 420 participants (25.7%) had gerd symptoms. risk factors with significant effects consisted of smoking, consumption of non-steroidal anti-inflammatory drugs (nasids), overeating, chronic diseases, tea and coffee consumption and gerd in spouse. conclusions the prevalence of gerd among people living in mashhad was above the average prevalence in other cities of iran. however, ri...

OBJECTIVES The pathogenesis of middle ear infections in children is multifactorial and includes infection, anatomical factors, impaired immunologic status, allergy, familial predisposition, male sex, method of feeding and environmental factors. Glue ear remains the commonest cause of deafness in childhood. Gastroesophageal reflux (GOR) is a common problem in the newborn and preschool periods. R...

BACKGROUND The pathophysiology of refractory asthma is not well understood; thus, treatment modalities are not targeted to specific phenotypes but rather to a broad-based treatment approach. The objective of this study was to develop refractory asthma phenotypes based on bronchoscopic evaluation and to develop from this information specific, directed, personalized therapy. METHODS Fifty-eight...

Treatment of gastroesophageal reflux disease in the United States today is binary, with the majority of patients with gastroesophageal reflux disease being treated with antisecre-tory medications and a minority of patients, typically those with volume regurgitation, undergoing Nissen fundoplication. However, there has been increasing dissatisfaction with proton pump inhibitor therapy among a si...

introduction: laryngopharyngeal reflux (lpr) is considered an important cause of voice disorder. we aimed to determine the frequency of lpr in patients with voice disorder and the association between koufman reflux symptom index (rsi), reflux finding score (rfs), gastroesophageal reflux disease (gerd), and proximal acid reflux in these patients. materials and methods: we performed a prospective...