OBJECTIVE A systematic literature search and review of the best evidence for intensive care treatment of refractory status epilepticus in children using continuous infusion of midazolam or anesthetic agents. DESIGN MEDLINE and EMBASE search before December 2013 using key words and/or Medical Subject Headings identified English-language citations that were screened for eligibility and used if ...

UNLABELLED Obstructive sleep apnea (OSA) commonly coexists with epilepsy, and treatment of OSA may decrease seizure frequency. However, it is unclear whether patients with medically refractory epilepsy have a higher incidence of OSA compared with well-controlled epilepsy patients and whether the two groups carry different risk factors. PURPOSE This study aimed to investigate the presence of O...

OBJECTIVE We aimed to find the prognostic factors to detect the patients who fail the treatment of epilepsy, in the early stages of the disease. MATERIALS &METHODS This study was done on the epileptic patients attending the Neurology Clinic of Mofid Children's Hospital, Tehran, Iran from September 2013 to October 2014. After defining the criteria for exclusion and inclusion, the patients were...

BACKGROUND The main purpose of the current study was to determine the effect of treating helicobacter pylori (HP) infection on seizure frequency in patients with refractory epilepsy. METHODS A small sample of adult patients above 18 years of age with a diagnosis of refractory epilepsy was studied at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, from January 2009 thr...

Background: In this study, we compared the efficacy and safety of propofol and midazolam in treatment of children’s refractory status epilepticus. Methods: We recruited 32 patients with refractory status epilepticus. Of those, 16 were treated primarily with midazolam and 16 received propofol. Results: We achieved complete seizure control in 6 (38%) patients treated by midazolam, and in 10 (63%)...

objective neuropsychological impairment is an important co-morbidity of chronic epilepsy. the aim of this study was to determine the state of the cognitive and motor development of patients with refractory epilepsy. materials & methods  we studied 150 consecutive children with epilepsy who were referred to mofid children hospital, a third level public referral university hospital in tehran, ira...

Background: The usefulness of the modified Atkins diet (mAD) in refractory epilepsy in adults has been rarely investigated. We aimed to evaluate the efficacy of mAD in adult with refractory epilepsy. Methods: In a controlled randomized clinical trial, we enrolled 66 refractory adult epileptic cases from February 2010 to December 2012. The patients were randomly divided into two groups, case gro...

OBJECTIVE To evaluate the long-term benefit and safety of everolimus for the treatment of medically refractory epilepsy in patients with tuberous sclerosis complex (TSC). METHODS Everolimus was titrated over 4 weeks and continued an additional 8 weeks in a prospective, open-label, phase I/II clinical trial design. Participants demonstrating initial benefit continued treatment until study comp...

background: in this study, we compared the efficacy and safety of propofol and midazolam in treatment of children’s refractory status epilepticus.   methods: we recruited 32 patients with refractory status epilepticus. of those, 16 were treated primarily with midazolam and 16 received propofol.   results: we achieved complete seizure control in 6 (38%) patients treated by midazolam, and in 10 (...