RA is common and costly for individuals, health services and societies. Current guidelines for the management of RA highlight the importance of early administration of DMARDs and the titration of therapy against disease activity to try and achieve remission. Reasonable evidence exists to show that early institution of DMARDs reduces the rate of progression of radiological damage in the long ter...

Abstract. In this study, a new regional Earth system model is developed and applied to the Med-CORDEX (Coordinated Regional Climate Downscaling Experiment) region. The ENEA-REG made up of two interchangeable climate models as atmospheric components (RegCM, REGional Model, WRF, Weather Research Forecasting), river (Hydrological Discharge, HD), an ocean (Massachusetts Institute Technology General...

1 Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK 2 Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neuroscience, University College London, London WC1N 1PJ, UK 3 Wellcome Department of Imaging Neuroscience, UCL Institute of Neurology, University College London WC1N 3BG, UK 4 Section of Neurology, ...

In both Basidiomycotina and Ascomycotina, Poly B-411 decolorization was an excellent indicator of the ability to cause white rot: 109 of the 110 isolates of brown rot fungi tested definitely did not decolorize Poly B-411, and 392 of the 401 mainly active isolates of white rot fungi decolorized Poly B-411. The Bavendamm (tannic acid) reaction was a less reliable test: of 74 white rot isolates ex...

The expression and functions of microRNA (miR)-411 have been investigated in several types of cancer. However, until now, miR-411 in human breast cancer has not been examined. The present study investigated the expression, biological functions and molecular mechanisms of miR‑411 in human breast cancer, discussing whether it offers potential as a therapeutic biomarker for breast cancer in the fu...

Santosh Bhaskaran*, Rohan Dudhale, Jyotsana Dixit, Ajit Sahasrabuddhe and Pandit B. Vidyasagar Biophysics Laboratory, Department of Physics, University of Pune, Pune 411 007, INDIA Department of Microbiology, P.E.S. Modern College of Arts, Science and Commerce, Ganeshkhind, Pune 411 053 INDIA. $ Haffkine Institute for Training, Research and Testing, Parel, Mumbai 400 012, INDIA Department of Mi...

Though, according even to the most pessimistic forecasts, Hungary is expected to remain amongst the regions with good quality grapevine growing conditions in the future, the expected frequency and the impact of extreme climatic events are rather serious warning signs. In this study first some impactful climatic indicators are analyzed which are of high importance in grapevine production. Histor...

BACKGROUND Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscle disorder, which is linked to the contraction of the D4Z4 array at chromosome 4q35. Recent studies suggest that this shortening of the D4Z4 array leads to aberrant expression of double homeobox protein 4 (DUX4) and causes FSHD. In addition, misregulation of microRNAs (miRNAs) has been reported in muscular dy...

The Response of Consumption in Russian Households to Economic Shocks This paper examines the extent to which consumption in Russian households responds to exogenous income shocks. During the time period studied in this paper (1994 – 1998), Russia experienced two major economic crises. Both featured extreme movements in the real ruble-dollar exchange rate. The price of oil, which is typically th...