the purpose of this study was to determine the role of streptococcal m protein in naturally-occurring cd4+cd25+ regulatory t cells (ntregs) function and development in rheumatic heart disease in iraqi patients. streptococcus pyogenes was isolated for subsequent m protein extraction. also, peripheral blood ntregs and cd4+ t cells were isolated by using magnetic cell separation system. tissue cul...

objective(s): regulatory t cells, including cd4+cd25+fox3+ and cd8+cd28- cells play an important role in regulating the balance between immunity and tolerance. since multiple sclerosis is an inflammatory autoimmune disease, regulatory t cells are considered to be involved in its pathogenesis. in this study, we investigated the circulatory numbers of the two mentioned types of regulatory t cells...

Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral blood naïve CD4+ T cells were co-cultured with ASCs derived from breast cancer or normal breast ...