THE effects of the alkaloid colchicine as a mitotic poison were first described by Lits [1934] and Dustin [1934], and the nature of its action has been further studied recently by Ludford [1936]. Amoroso [1935] has reported experiments on the inhibition of tumour growth in mice and a dog by injection of colchicine, although uniform results have not been obtained by subsequent workers. In common...

An IARC working group of 19 experts in chemical carcinogenesis and seven industrial or governmental observers met in October 1996 in Lyon to prepare updated monographs and evaluations on crystalline and amorphous silica, palygorskite (attapulgite), sepiolite, and wollastonite. Monographs on these agents were published previously in Volume 42 of the IARC Monographs (1). Also evaluated by the gro...