BACKGROUND Measurement of plasma renin is important for the clinical assessment of hypertensive patients. The most common methods for measuring plasma renin are the plasma renin activity (PRA) assay and the renin immunoassay. The clinical application of renin inhibitor therapy has thrown into focus the differences in information provided by activity assays and immunoassays for renin and proreni...

1. Hepatic elimination of renin was measured in 10 well-compensated cardiac patients with normal liver function during a control period and during a period of reduced hepatic plasma flow, induced by physical exercise (seven patients) or intravenous infusion of lysine vasopressin (three patients). 2. Hepatic renin elimination rate (hepatic plasma flow x arterial-hepatic vein difference of plasma...

conclusions garlic powder consumption can reduce blood pressure, yet in this model, it did not have an effect on the interaction between renin angiotensin system and nitric oxide inhibition. results at the beginning and at the end of experiments, systolic blood pressure was higher in the hypertensive groups than the normotensive group. however, at the end of the study, diastolic blood pressure ...

Renin and erythropoietin activities were measured in the plasma of 110 rats exposed to various conditions designed to dissociate the two renal "hormones." In acute experiments, intraperitoneal injection of polythiazide increased renin activity but did not change erythropoietin activity; exposure to low oxygen tension increased erythropoietin activity and caused an insignificant decrease in reni...

This study was designed to determine particular changes in the renin gene expression and activity in renal cortex and medulla after AT(1) receptor blockade. It was found that two-week-treatment with AT(1) blocker losartan induced an increase in tissue renin activity in both parts of kidney causing subsequent elevation of plasma renin activity. Renin mRNA in losartan-treated rats was increased o...

In 106 patients with essential hypertension and different plasma renin activity several hormonal and metabolic factors were studied: urinary excretion of catecholamines, blood levels of cholesterol and triglycerides, levels of glycaemia and insulinaemia after glucose load and plasma fibrinolytic activity. The plasma renin activity in 46.2 percent of patients was normal, whereas in 25.5 percent ...

FUKUCHI, S., TAKENOUCHI, T. and NAIKAJTSA, K. Effect of Furosemide Administration and Upright Position on Plasma Renin Activity and Angootensin ‡U in Hypertension. Tohoku J. exp. Med., 1973, 111 (1), 71-78 Both plasma renin activity and angiotensin ‡U during recumbency measured by radioimmuno assay, were normal in essential hypertension, chronic glomerulonephritis and bilateral renal artery ste...

Vascular renin-like activity was studied in the aortas and the cerebral microvessels of Sprague-Dawley rats and in the aortas of spontaneously hypertensive rats. Methods were employed to maximize detection of tissue renin and to simultaneously minimize contamination of that activity by either plasma renin or nonspecific proteases capable of angiotensin I generation. To this end, renin activity ...