Renovascular hypertension alters cardiac structure and function. Autophagy is activated during left ventricular hypertrophy and linked to adverse cardiac function. The angiotensin II receptor blocker, valsartan, lowers blood pressure and is cardioprotective, but whether it modulates autophagy in the myocardium is unclear. We hypothesized that valsartan would alleviate autophagy and improve left...

Angiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin-angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary-vagal complex (nuc...

Renovascular disease includes renal artery stenosis, renovascular hypertension, and azotemic renovascular disease (ischemic nephropathy). Renovascular hypertension is defined as an elevated blood pressure caused by renal hypoperfusion, usually resulting from anatomic stenosis of the renal artery and activation of the renin-angiotensin system. It accounts for 1% to 2 % of all cases of hypertensi...

background: hawthorn species decreases blood pressure and relaxes precontracted vessels. this study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension. methods: six groups of male sprague-dawley rats, each containing 6 to 8 rats, were studied. the groups comprised of...

This issue of Hypertension features an article by Imanishi and colleagues entitled "Aspirin Lowers Blood Pressure in Patients With Renovascular Hypertension." In their study, Imanishi and coworkers compared the effects of intravenously administered aspirin on arterial blood pressure, plasma renin activity in the renal veins and aorta, and plasma levels of prostaglandin E2 in the renal veins and...

BACKGROUND Pregnancy losses and atherosclerotic disease may be etiologically linked through underlying pathology. We examined whether miscarriage and stillbirth increase later risk of myocardial infarction, cerebral infarction, and renovascular hypertension. METHODS AND RESULTS Among women pregnant at least once between 1977 and 2008, we identified a cohort of women with miscarriages, stillbi...

INTRODUCTION Renovascular hypertension in children is a very rare illness. It occurs as a result of the imbalance between hypotensive and hypertensive systems. Renal ischaemia (95% of the cases) and the shortening of hipotensive factors (5% of the cases) are responsible for the production mechanism of renovascular hypertension in children. In order to make an early diagnosis regarding the renov...

UNLABELLED Interventional radiologic procedures offer a significant and expanding role in the management of various renovascular diseases including renal artery stenosis, renal artery aneurysm and pseudoaneurysm, renal vascular malformations, renal tumours, trauma, and resistant hypertension. In this article, we discuss these entities in the context of currently accepted definitions, incidence,...

Dipeptidyl peptidase IV converts neuropeptide Y(1-36) (Y(1)-receptor agonist released from renal sympathetic nerves) to neuropeptide Y(3-36) (selective Y(2)-receptor agonist). Previous studies suggest that Y(1), but not Y(2), receptors enhance renovascular responses to angiotensin II in kidneys from genetically-susceptible animals. Therefore, we hypothesized that inhibition of dipeptidyl peptid...

Cerebral vessels of the spontaneously hypertensive rat (SHR) are less susceptible to disruption of the blood-brain barrier to proteins during acute hypertension than normotensive controls. This protective adaptation in SHR during acute hypertension is thought to be due to cerebral vascular hypertrophy which leads to increased vascular resistance and attenuation of the increase in cerebral blood...