killed 18 hr after administration of the labeled drug. Analysis of the various brain areas showed that with the exception of the cerebellum, residual E3H]reserpine concentrations were markedly iowered in all brain areas (Table 2), indicating that mutual ~eserpine-tetrabe~~ne sites are w~d~pread in the brain. The other way of establishing the specificity of reserpine binding was by taking advant...

A new, non-invasive method for measuring reserpine-induced tremor in rodents is described here. The test procedure is based on the piezo-electric principle and was evaluated using the tremorogenic compound reserpine and the stereotypies-inducing drug apomorphine. Whereas for reserpine an orderly and dose-related increase in activity was observed, no such effect was detected with apomorphine. In...

1. a. Reserpine is a risk factor. Overall, the incidence of breast cancer is 10.47 per 100,000 women-years in reserpine users and 6.14 per 100,000 women-years in nonusers. Moreover, among the non-obese, the rate ratio is: 6.40/4.10 = 1.6. Looking in the non-obese women avoids potential confounding by obesity if it is a risk factor. b. Obesity is also a risk factor. The overall incidence rates f...

The potent antihypertensive drug reserpine inhibits the transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Reserpine acts by binding almost irreversibly to the vesicular amine transporter, and this interaction has been used both to study the mechanism of transport and to purify the protein responsible. Recent isolation of a cDNA for the rat chromaffin granule a...

Mammary gland development and secretion in male rats were induced by single injections of reserpine. The lactogenic effect of reserpine was most marked when a dose of 1mg/kg was given. The alveoli and ducts of the male mammary glands were greatly distended with milky secretion. Similar changes in the glands were also observed but in a smaller number of animals when a dose of 0.5-0.75mg/kg was g...

Background and Objectives: Chlorogenic acid, a natural polyphenolic compound has been reported to possess neuroprotective and antioxidant activities, but the effect of chlorogenic acid on orofacial dyskinesia has not been explored till date, so the aim of the present study was to investigate the effect of chlorogenic acid on reserpine-induced orofacial dyskinesia in Wistar male albino rats. Met...

The mechanism of resistance to the catecholamine depleting effects of reserpine in morphine tolerant rats was examined. In vitro, morphine did not alter reserpine 3 inhibition of H-norepinephrine uptake by synaptic vesicles. Similarly, uptake by vesicles isolated from morphine tolerant animals was as susceptible to reserpine inhibition as that of corresponding preparations from saline treated c...

With pronethalol, quinidine, and reserpine it was necessary to increase the dose of acetylstrophanthidin which produced arrhythmia in combination with vagal stimulation. However, in reserpine-treated animals, quinidine and pronethalol were ineffective. The capability of large doses of acetylstrophanthidin to produce ventricular arrhythmia was not diminished by quinidine, pronethalol, or reserpi...

With pronethalol, quinidine, and reserpine it was necessary to increase the dose of acetylstrophanthidin which produced arrhythmia in combination with vagal stimulation. However, in reserpine-treated animals, quinidine and pronethalol were ineffective. The capability of large doses of acetylstrophanthidin to produce ventricular arrhythmia was not diminished by quinidine, pronethalol, or reserpi...

      Murraya koenigii L. (Rutaceae), commonly known as curry leaf tree, closely associated with south India where the word “curry” originates from the Tamil “kari” for spiced sauces. Curry leaves are a rich source of carbazole alkaloids which possess various biological activities such as antitumor, antioxidant and anti-inflammatory. Curry leaf has a potential role in the treatment of diabetes....