This is a retrospective study on clinical course and treatment response of patients with thyroid hot nodule, referred to nuclear medicine department of Shariati Hospital from 1360 to 1377. From the total 58 patients with average age of 43 yr and incidence peak of 40 yr, 81% were female and 19% were male. 64% of the patients were thyrotoxic and 36% were euthyroid at presentation. Thyrotoxi...

radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. the method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. iodine-131 (i-131) acts by the destructive effect of short-range beta radiation on ...

Post-treatment or diagnostic whole-body radioiodine scintigraphy is widely used to assess the residual, recurrence, or metastases of differentiated thyroid carcinoma because of the high sensitivity and accuracy that this assessment provides. While bearing in mind all the diagnostic potential of this test, we have to consider its’ potential pitfalls, as well. Herein, we present 4 patients with d...

UNLABELLED In vitro and in vivo experiments from our laboratory and others have suggested that the combination of thymidylate synthase (TS) inhibitor and radiolabeled iododeoxyuridine (IdUrd) is synergistic. Efficacy is limited by drug resistance, which is often mediated by TS overexpression. We designed an in vivo electrogene transfer (EGT) model for delivering antisense TS plasmid (ATS) into ...

Introduction: High-dose radioactive iodine therapy in differentiated thyroid cancer (DTC) may adversely affect the salivary gland function. This study is aimed to evaluate the effect of radioactive iodine (RAI) with dose of 100 mCi in DTC patients compared to lower doses of less than 30 mCi in hyperthyroid cases. Methods: Fifty four patients (13 men and 41 women) age: 42.3±14.3 (21-71) years w...

differentiated thyroid carcinomas usually show good uptake and response to i-131 ablative treatment. in this study, 90 patients following near total thyroidectomy who were referred to our institute for i-131 therapy are retrospectively studied. the patients are divided in two groups. group 1 revealed complete ablation after one dose of i-131. group 2 needed more than one dose of i-131 for ablat...

BACKGROUND Radioactive iodine 131 ((131)I) therapy has long been used in the treatment of differentiated thyroid cancers (DTC). While salivary and lacrimal glandular complications secondary to (131)I therapy are well documented, there is little in the literature addressing nasolacrimal duct obstruction (NLDO). We aimed to evaluate the frequency of (131)I therapy-acquired NLDO, its correlation t...

Background. The most appropriate therapy for papillary microcarcinoma (PMC) is controversial. Methods. We reviewed the therapy and outcome of 407 patients with PMC. Results. Three hundred-eighty patients underwent total thyroidectomy, and 349 patients received I-131 therapy. The median followup was 5.3 years. Forty patients developed recurrent disease. On univariate analysis, development of dis...