The use of the quantitative nasal culture was investigated as a means of evaluation of new antimicrobial drugs in man. Cyclacillin was somewhat more active in vitro than penicillin G against penicillin G-resistant organisms. Cyclacillin was highly effective in suppressing staphylococci susceptible to penicillin G in nasal carriers but did not suppress staphylococci resistant to penicillin G. Al...

Introduction: A large number of infectious processes are associated with opportunistic microorganisms. The phenotype antibiotic resistance such pathogens is multidrug-resistant strains the presence various β-lactamases. Our objective was to determine phenotypic and genotypic features staphylococci, enterobacteria, non-fermenting Gram-negative bacteria – cause diseases in patients health facilit...

Coagulase negative staphylococci have been recognized as one of the important cause hospital acquired infections in recent past. It has become difficult to manage these due emergence multidrug resistance them. The aim this study was determine antibiotic sensitivity trend all Staphylococci isolates using modified Kirby- Bauer disk diffusion technique. To assess for coagulase staphylococci, Kirby...

introduction: drug resistant staphylococci are the most important agents of nosocomial infections. in this survey, effect of different antibiotics on these bacteria and their drug resistance was investigated. methods: the study included 500 strains of staphylococci. minimum inhibitory concentrations of all antibiotics was determined by the broth macro dilution technique and standard methods fro...

A prospective study was conducted to determine the prevalence of aminoglycoside-resistant Staphylococcus aureus and coagulase-negative staphylococci before and after the introduction of amikacin as the sole aminoglycoside used in our burn unit, adult intensive care unit, and neonatal intensive care unit. Pharyngeal or endotracheal cultures, as well as superficial surveillance cultures, were col...

Eight cephalosporins were tested for their activity against methicillin-susceptible and methicillin-resistant, coagulase-negative staphylococci and for their resistance to beta-lactamase from methicillin-resistant, coagulase-negative staphylococci. Susceptibility testing by the agar plate method was evaluated for the effect of inoculum size and duration of incubation. Methicillin-susceptible, c...

Sutherland, R. (Beecham Research Laboratories Ltd., Betchworth, Surrey, England), and G. N. Rolinson. Characteristics of methicillin-resistant staphylococci. J. Bacteriol. 87:887-899. 1964.-Cultures of naturally occurring methicillin-resistant staphylococci obtained from a number of hospitals were examined for the nature and degree of resistance to methicillin and other antibiotics. All the cul...

Drug resistant bacteria have been a growing threat to the community and hospitals due to the misuse of antibiotics by humans, industrialization, and lack of novel antimicrobials currently available. Little is known about the prevalence of drug resistant bacteria in nonhealthcare environments in Brunei Darussalam and about how antibiotic resistant genes are transferred within these environments....

The comparative in vitro activity of RU 64004 (also known as HMR 3004), a new ketolide antibiotic, was tested by agar dilution against approximately 500 gram-positive organisms, including multiply resistant enterococci, streptococci, and staphylococci. All streptococci were inhibited by < or = 1 microg of RU 64004 per ml. The ketolide was more potent than other macrolides against erythromycin A...