PURPOSE To characterize longitudinal structural changes in early stages of late-onset retinal degeneration to investigate pathogenic mechanisms. METHODS Two affected siblings, both with a S163R missense mutation in the causative gene C1QTNF5, were followed for 8+ years. Color fundus photos, fundus autofluorescence images, near-infrared reflectance fundus images, and spectral domain optical co...

The purpose is report a case of reticular pattern dystrophy of the retinal pigment epithelium (RPE) in a 56year-old woman with breast cancer. Images were obtained using fundus photography, fundus autofluorescence (FAF) imaging, and optical coherence tomography (OCT). The patient complained of bilateral metamorphopsia for 2 months. She underwent surgical treatment and chemotherapy for breast can...

Without claiming any close analogy between the autolytic changes and pigmentation in pathological processes, it has, we believe, been shown that iron-containing, as well as other kinds of pigments, may be formed during the autolytic degeneration of parenchymatous cells independently of the hemoglobin in the blood stream, and hence may be derived from the proteid constituents of the cell itself.

The aim of this study was to investigate the dermoscopic changes in acquired melanocytic naevi in a large paediatric population over an interval of several years. Images of 717 melanocytic naevi were obtained from 160 consecutive patients. Dermoscopic pigment pattern changes were observed in one of two lesions after a follow-up of one year, in 34 of 295 lesions (11.5%) after 2 years, in 40 of 1...

Introduction: Oral Lichen Planus (OLP) is one of the most common mucocutaneous lesion, and its etiologic factors have not been elucidated yet. OLP has two different clinical forms including reticular and erosive. Mast cells function in non-specific immunology is an etiologic factor involved in the formation of lichen planus. This study aimed at determining the pattern of mast cells presence in ...

Purpose. To report an association between reticular pseudodrusen, located above the retinal pigment epithelium (RPE), and Early Onset Drusen (EOD) as described using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods. Eight patients (16 eyes) with EOD were examined. EOD were classified into three entities called Large Colloid Drusen (LCD), Malattia Leventinese (ML), and Cuticular Dr...