BACKGROUND/AIMS Retinal toxicity is one of the most commonly discussed and concerning adverse effects of vigabatrin (VGB). The present study explored the relationship between the VGB elicited retinal toxicity, photopic exposure, and taurine deficiency, aiming at screening for risk factors to minimize the adverse effects of VGB. METHODS The effects of VGB on function and morphology of mouse re...

Hydroxychloroquine (HCQ) is an antimalarial medication that can also be used to treat autoimmune diseases. However, it can produce irreversible changes to the retina that lead to visual impairment. The aim of this study was to determine the proportion of patients treated with HCQ who develop retinal toxicity and the risk factors for the development of HCQ-induced retinal toxicity among Iranian ...

n engl j med 363;16 nejm.org october 14, 201

We present a case of a 67-year-old female who presented with a twelve-month history of progressive blurred vision in both eyes. The patient was on hydroxychloroquine 200 mg twice a day for eight years for the treatment of scarring alopecia. Two years prior to presenting, the patient was found to have chronic kidney disease stage 3 secondary to hypertension. Examination revealed bilateral reduce...

Background: Hydroxychloroquine (HCQ) is an antimalarial drug often employed in the treatment of various diseases, as a basic for prolonged period time. Materials and Methods: Screening tests were analyzed descending order early detection changes HCQ toxicity. Results: The first ocular result toxicity are those found during visual field test, typical image fundus that highlights bull’s-eye lesio...