A compact neutron spectrometer, based on a CH foil for the production of recoil protons and CR-39 detection, is being developed for the measurements of the DD-neutron spectrum at the NIF, OMEGA, and Z facilities. As a CR-39 detector will be used in the spectrometer, the principal sources of background are neutron-induced tracks and intrinsic tracks (defects in the CR-39). To reject the backgrou...

186 Rhenium-labeled anti-CD20 antibody radioimmunotherapy followed by autologous peripheral blood stem cell transplantation in patients with relapsed or refractory non-Hodgkin lymphoma We read with interest the article of Gopal et al 1 on the use of high-dose radioimmunotherapy in relapsed follicular lymphoma. Here, we report on our experience using a rhenium 186 (186 Re)– radiolabeled chimeric...

OBJECTIVE Rhenium is one of the most valuable elements for internal radiotherapy because (186)Re and (188)Re have favorable physical characteristics. However, there are problems when proteins such as antibodies are used as carriers of (186/188)Re. Labeling methods that use bifunctional chelating agents such as MAG3 require the conjugation of the (186/188)Re complex to protein after radiolabelin...

Introduction: The palliative care in patients with bone metastasis includes variety of techniques such as conventional analgesics, surgery, external beam radiotherapy, hormone therapy, chemotherapy and using bone-seeking radiopharmaceuticals. Even some of the recent works used combined methods like chemotherapy and radionuclide therapy or using radionuclide therapy as adjuvant ...

UNLABELLED The clinical picture of bone metastases is manifested by pain and loss of mechanical stability. Standard treatment options for bone metastases include external beam radiotherapy and the use of analgesics. Due to a large number of lesions in many patients, the use of radionuclide therapy with beta emitters may be preferable. Re-186 hydroxyethylidene diphosphonate (Re-186 HEDP) is one ...

Cu(II)-catalysed decomposition of hydrogen peroxide at alkaline pH in the presence of etidronic acid (HEDP) showed a sigmoid kinetic profile typical of autocatalytic reactions. However, the reaction abruptly stopped well before all hydrogen peroxide had decomposed, and further addition of Cu(II) and HEDP did not restart the reaction. Results of a mechanistic study suggest that the reaction invo...

Although external beam radiation is an essential component to the current standard treatment of primary brain tumors, its application is limited by toxicity at doses more than 80 Gy. Recent studies have suggested that brachytherapy with liposomally encapsulated radionuclides may be of benefit, and we have reported methods to markedly increase the specific activity of rhenium-186 ((186)Re)-lipos...