Talin is an integrin adaptor, which controls integrin activity in all hematopoietic cells. How intracellular signals promote talin binding to the integrin tail leading to integrin activation is still poorly understood, especially in leukocytes. In vitro studies identified an integrin activation complex whose formation is initiated by the interaction of active, guanosine triphosphate (GTP)-bound...

The Rap1-GTP interacting adapter protein (RIAM) is an important protein in Rap1-mediated integrin activation. By binding to both Rap1 GTPase and talin, RIAM recruits talin to the cell membrane, thus facilitating talin-dependent integrin activation. In this article, we studied the role of the RIAM Ras-association (RA) and pleckstrin-homology (PH) domains in the interaction with Rap1. We found th...

Adaptive immunity depends on lymphocyte adhesion that is mediated by the integrin lymphocyte functional antigen 1 (LFA-1). The small guanosine triphosphatase Rap1 regulates LFA-1 adhesiveness through one of its effectors, Rap1-interacting adapter molecule (RIAM). We show that RIAM was recruited to the lymphocyte plasma membrane (PM) through its Ras association (RA) and pleckstrin homology (PH) ...

a r t i c l e i n f o Keywords: Strategic environmental assessment (SEA) Rapid impact assessment matrix (RIAM) Analytic Hierarchy Process (AHP) Integrated environmental score (IES) Indicator weighting Urban planning Strategic environmental assessment (SEA) has become an increasingly important decision-support tool for providing information on the environmental implications of a policy, plan, or...

Integrins are a/b heterodimeric transmembrane receptors that are expressed on all cells. They provide stable adhesion of cells to the extracellular matrix or to other cell counter receptors by forming complex adhesion sites, which serve as signaling platforms (outside-in signaling) that induce cell polarity, migration, survival, and proliferation. Because integrins reside in an inactive state, ...

Because a significant portion of the topography in Japan is characterized by steep, complex terrain, which results in a complex spatial distribution of wind speed, great care is necessary for selecting a site for the construction of Wind Turbine Generators (WTGs). We have developed a CFD model for unsteady flow called Research Institute for Applied Mechanics, Kyushu University, COMputational Pr...

This project evaluates an Environmental Impact Assessment (EIA) for Kannakuruchi Town Panchayat, Salem by using Rapid Impact Assessment Matrix (RIAM) tool. EIA analysis has four sequential phases such as identification, analysing, prediction and policy making. Identification involves characterizing the existing physical, social, economic, and ecological environment due to rapid urbanization and...

Takala, Heikki Three proteins regulating integrin function – filamin, 14-3-3 and RIAM Jyväskylä: University of Jyväskylä, 2011, 78 p. (Jyväskylä Studies in Biological and Environmental Science ISSN 1456-9701; 232) ISBN 978-951-39-4523-7 (nid.) ISBN 978-951-39-4524-4 (PDF) Yhteenveto: Kolme integriinin toimintaa säätelevää proteiinia – filamiini, 14-3-3 ja RIAM Diss. Integrins are transmembrane ...

Engagement of the TCR or of chemokine receptors such as CXCR4 induces adhesion and migration of T cells via so-called inside-out signaling pathways. The molecular processes underlying inside-out signaling events are as yet not completely understood. In this study, we show that TCR- and CXCR4-mediated activation of integrins critically depends on the membrane recruitment of the adhesion- and deg...

In this issue of Blood, Stritt et al show that platelet functions dependent on integrin activation are unimpaired in mice lacking the Rap1-GTP-interacting adaptor molecule (RIAM).