In this investigation, roll compaction/dry granulation (RCDG) process was optimized for formulation of model amorphous drug candidate with fine-fluffy nature and poor flowability. Three operating parameters the roller speed, the hydraulic pressure and the granulator speed on the Alexanderwerk WP 120 Pharma Roll Compactor were varied. The planned response variable for study was % retention over ...

Abstract The aim of this study was to investigate powder mechanics upon compression using data obtained from force-displacement (F-D) curves. Kawakita model analysis adopted in order compare the pressure-volume reduction relationship drug powders relation F-D Experiments were carried out on six drugs (metronidazole, metformin, secnidazole, ciprofloxacin, norfloxacin, and mebeverine). compressed...

Processing powder blends can present a number of challenges: component powders may be poorly flowing in the process, the blends may be susceptible to segregation, or the formation of agglomerates may affect homogeneity. Granulation is used in a range of industries and applications to combine multiple components of a blend into a more free-flowing, homogeneous intermediate product for downstream...

This paper introduces a finite memory compactor called convolutional compactor that provides compaction ratios of test responses in excess of 100x even for a very small number of outputs. This is combined with the capability to detect multiple errors, handling of unknown states, and the ability to diagnose failing scan cells directly from compacted responses. A convolutional compactor can be ea...

A new method is presented for designing space compactors for either deterministic testing or pseudorandom testing. A tree of elementary gates (AND, OR, NAND, NOR) is used to combine the outputs of the circuit-under-test (CUT) in a way that zero-aliasing is guaranteed with no modification of the CUT. The elementary-tree is synthesized by adding one gate at a time without introducing redundancy. ...

Compacting garbage collector (GC) is widely used due to its good properties of in-place collection and heap de-fragmentation. In addition, it supports fast bump-pointer allocation and provides good access locality. Most known commercial JVM or CLR implementations use compaction algorithm in certain garbage collection scenarios, such as in full heap or mature object space collections. LISP2 comp...