The effects of combined exposure to n-butyl alcohol and n-butyl acetate on rotarod performance and hot plate behaviour in rats and respiratory rate in mice were investigated in the condition of an acute inhalation experiment. Rotarod performance and hot-plate behaviour were tested in rats exposed to various concentrations of n-butyl alcohol, n-butyl acetate and their mixture consisting of 50 Vo...

Target Audience This study is targeted at Neuroscientists interested in experience-dependent structural brain plasticity. Purpose This study investigates experience-related structural plasticity in response to a standard motor training task in adult mice. To cover a wider array of structural changes we test for volume changes based on T2-weighted images and microstructural changes based on maps...

Increased use of gene manipulation in mice (e.g., targeted or random mutagenesis) has been accompanied by increased reliance on a very few rapid and simple behavioral assays, each of which aspires to model a human behavioral domain. Yet, each assay comprises multiple traits, influenced by multiple genetic factors. Motor incoordination (ataxia), a common characteristic of many neurological disor...

introduction: aluminum is known as a neurotoxic element which causes neurodegeneration, learning deduction and movement disorders. aluminum ions in the brain cause serious problems such as alzheimer, parkinson and other degenerative diseases. on the other hand, zinc is a dietary element essential for several biological processes, modulates neurotransmission in brain regions and associates with ...

Objective: In addition to attention deficits and hyperactivity it is common for children with ADHD to display impaired fine and gross motor skills. The spontaneously hypertensive (SH) rat model of ADHD displays impaired motor learning [1]. We used this characteristic to study if the recently described acoustic noise benefit in learning in children with ADHD [2, 3] is also observed in the SH ra...

background research in the area of herbal psychopharmacology has clearly improved in recent decades. self-administration of herbal medicines has been the most popular therapeutic alternative to standard medicine. objectives since the extract of echium amoenum exhibits an anxiolytic effect, the aim of this study is to evaluate the anxiolytic and hypnotic effects in mice of the aqueous and ethano...

Caspr3 (Contactin-associated protein-like 3, Cntnap3) is a neural cell adhesion molecule belonging to the Caspr family. We have recently shown that Caspr3 is expressed abundantly between the first and second postnatal weeks in the mouse basal ganglia, including the striatum, external segment of the globus pallidus, subthalamic nucleus, and substantia nigra. However, its physiological role remai...

Background: Parturition depression is an important physiological problem, and several attempts have been made to ascertain this phenomenon. Natural monoterpenes like α-pinene numerous beneficial properties, but no studies done on their antidepressant potential in postpartum animals. Objectives: This study aimed determine the effects of prenatal administration antidepressant-like behavior mice f...