Afibrinogenemia or hypofibrinogenemia is a quantitative defect in fibrinogen. It is a rare disease with estimated frequency of 1 in 1,000,000 population. Routine preoperative screening tests of coagulation disorders are insufficient to detect subtle disorders of fibrinogen. Herein, we report a child who was supposed to undergo open cardiac surgery for a large atrial septal defect. Preoperative ...

realizing the cause of cushing's syndrome (cs) is one of the most challenging processes in clinical endocrinology. the long high dose dexamethasone suppression test (standard test) is costly and need an extended inpatient stay. in this study we want to show the clinical utility of the overnight 8 mg dexamethasone suppression test (dst) for differential diagnosis of cs in a referral center. retr...

A 78-year-old female presents to the emergency department with a traumatic hip fracture. Her past medical history is significant for atrial fibrillation for which she receives rivaroxaban 20 mg daily. Her dose was last taken 12 hours ago. Routine bloodwork conducted in the emergency department shows prothrombin time, international normalized ratio, and activated partial thromboplastin time with...

introduction: the role of ultrasonography in detection of pleural effusion has long been a subject of interest but controversial results have been reported. accordingly, this study aims to conduct a systematic review of the available literature on diagnostic value of ultrasonography and radiography in detection of pleural effusion through a meta-analytic approach. methods: an extended search wa...

introduction: hemothorax is one of the most prevalent injuries caused by thoracic traumas. early detection and treatment of this injury is of utmost importance in prognosis of the patient, but there are still controversial debates on the diagnostic value of imaging techniques in detection of hemothorax. therefore, the present study aimed to evaluate the diagnostic value of chest ultrasonography...

Many gynaecological units have a policy of performing routine coagulation tests in cases of missed abortion. For many years now, it has been accepted practice in our unit to perform routinely a platelet count, bleeding time (BT), clotting time (CT) and plasma fibrinogen (P. fib) level prior to evacuation in cases of missed abortion. We are not sure how or why these 4 tests came to be chosen as ...

BACKGROUND Conventional coagulation screening tests such as Prothrombin time, International normalized ratio (INR) and activated partial thromboplastin time are often used to predict bleeding in various clinical situations. We aimed to observe the effect of Fresh-frozen plasma (FFP) on these parameters. Methods Patients' demographics, pre- and post-transfusion coagulation parameters were note...

introduction: ultrasonography is currently being used as one of the diagnostic modalities in various medical emergencies for screening of trauma patients. the diagnostic value of this modality in detection of traumatic chest injuries has been evaluated by several studies but its diagnostic accuracy in diagnosis of pulmonary contusion is a matter of discussion. therefore, the present study aimed...