نتایج جستجو برای: rs12255372
تعداد نتایج: 72 فیلتر نتایج به سال:
Objetivo: Realizar um estudo relacionado a quatro polimorfismos em genes que podem estar associados à Síndrome Metabólica. Métodos: Foi realizada uma revisão sistemática partir do método PRISMA, com o número de aprovação CRD42022375987 pela PROSPERO, na qual foi utilizada bases dados PubMed os devidos descritores. Resultados: A presença SNP rs8050136 no gene FTO pode indicar alta associação pro...
In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. ...
Investigation of polymorphisms rs7903146 and rs12255372 in the TCF7L2 gene in biochemical markers of severity of type 2 diabetes mellitus (T2DM) in a sample of adults with T2DM Simone Morelo Dal Bosco, Cristiane dos santos Costa, Adriana Regina Bitello, Crislene Sippel, Rafaela Bastian, Maria Wollinger, Julio Dessoy, Olívia Bouchacourt, Rosangela Leipinitz, Veronica Contini, Claudete Rempel, Ju...
BACKGROUND Single nucleotide polymorphisms (SNPs) rs7903146 and rs12255372 located within TCF7L2 gene have been identified as the strongest common genetic risk factors for development of type 2 diabetes (T2D). We hypothesized that these genetic variants might increase the risk of T2D through regulation of alternative splicing or expression level of TCF7L2 in human adipose tissue. METHODOLOGY/...
Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D). However, the mechanisms by which these non-coding variants increase risk for T2D are not well-established. We used 13 expression assays to survey mRNA expression of multiple TCF7L2 splicing forms in up to 380 samples from eight types of human t...
BACKGROUND Coronary artery disease (CAD) shares common risk factors with type 2 diabetes (T2DM). Variations in the transcription factor 7-like 2 (TCF7L2) gene, particularly rs7903146, increase T2DM risk. Potential links between genetic variants of the TCF7L2 locus and coronary atherosclerosis are uncertain. We therefore investigated the association between TCF7L2 polymorphisms and angiographica...
BACKGROUND TCF7L2 gene variants have been associated with increased risk of type 2 diabetes and higher adiposity. Observational studies and short-term trials have suggested that macronutrients may modify these effects. However, to our knowledge, this has yet to be verified in long-term interventions. OBJECTIVE In a long-term intervention setting, we investigated the effects of TCF7L2 polymorp...
OBJECTIVE Variation in transcription factor 7-like 2 (TCF7L2) gene has been shown to be associated with type 2 diabetes and diabetes-related quantitative traits. We examined variation in a 0.1-Mb region surrounding marker DG10S478 for association with diabetes-related quantitative traits in 132 Mexican-American families of a proband with previous gestational diabetes mellitus (GDM). RESEARCH ...
Recently, many new loci associated with type 2 diabetes have been uncovered by genetic association studies and genome-wide association studies. As more reports are made, particularly with respect to varying ethnicities, there is a need to determine more precisely the effect sizes in each major racial group. In addition, some reports have claimed ethnic-specific associations with alternative sin...
Type 2 diabetes mellitus (T2DM) has been strongly associated with single nucleotide polymorphisms (SNPs) in the TCF7L2 gene. This study investigated association between rs12255372, rs7903146 gene and T2DM a Ghanaian population. A case-control design was used for this study. total of 106 patients 110 control participants were selected. Basic data collected included body mass index, blood pressur...
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