Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and ...

Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) lead to resistance to thyroid hormone (RTH). These TRβ mutants function in a dominant-negative fashion to interfere with the transcription activity of wild-type thyroid hormone receptors (TRs), leading to dysregulation of the pituitary-thyroid axis and resistance in peripheral tissues. The molecular mechanism by whic...

Patients with the syndrome of resistance to thyroid hormone (RTH) have clinical (tachycardia and anxiety) and biochemical (elevated thyroid hormones level) features of hyperthyroidism. Based on previous reports in pediatric patients with the RTH, antithyroid treatment in these patients is not indicated. Clinical and biochemical sequel of antithyroid therapy in an adult patient with RTH was not ...

Melanin possess radioprotective and scavenging properties, and its presence can affect the behavior of melanoma cells, its surrounding environment and susceptibility to the therapy, as showed in vitro experiments. To determine whether melanin presence in melanoma affects the efficiency of radiotherapy (RTH) we evaluated the survival time after RTH treatment in metastatic melanoma patients (n = ...

In this paper we establish a working definition of, and develop legal rationale for, the insertion of constitutional Right to Health (RTH) protection in Constitution Ireland. We propose that framework exists for judicial enforcement right health Ireland, as based on parallels drawn between Irish case law RSA, comparable common democracy with developed jurisprudential approach its RTH. When mode...

In 1977, Adleman, Manders and Miller had briefly described how to extend their square root extraction method to the general rth root extraction over finite fields, but not shown enough details. Actually, there is a dramatic difference between the square root extraction and the general rth root extraction because one has to solve discrete logarithms for rth root extraction. In this paper, we cla...

resistance to thyroid hormone is an uncommon condition. we report the clinical and laboratory findings of a case with both resistance to thyroid hormone and, a reduced capacity to produce and respond to thyroid hormone. rth is a disorder characterized by elevated circulating thyroid hormones, state of non-suppressed pituitary tsh secretion and refractoriness to hormone action in peripheral tiss...

Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome of impaired tissue responsiveness to thyroid hormones (TH) characterised by high circulating TH in the presence of unsuppressed thyroid-stimulating hormone (TSH). TH achieve their action on the heart chiefly via thyroid hormone receptor alpha 1 (TRa1), which is the TH receptor (TR) isoform predominantly expressed in such an ...

Order statistics arising from exponentiated gamma (EG) distribution are considered. Closed from expressions for the single and double moments of order statistics are derived. Measures of skewness and kurtosis of the probability density function of the rth order statistic for different choices of r, n and /theta are presented. Recurrence relations between single and double moments of r...