phenolic and flavonoid compounds are secondary metabolites of plants which possess various activities such as anti-inflammatory, analgesic, anti-diabetes and anticancer effects. it has been established that these compounds can scavenge free radicals produced in the body. because of this ability, not only the plants containing phenolic and flavonoid compounds but also, the pure compounds are use...

Rutin is a nonmutagenic flavonol glycoside, whereas its aglycone quercetin is mutagenic. Cell-free preparations from fecal cultures (fecal preparations) contain a beta-glucosidase that, when incubated with rutin, hydrolyzes it to quercetin. This activity can be further induced when rutin is added to the fecal culture from which the cell-free preparation is made. When vitamin pills that contain ...

This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the se...

This study investigated the antifatigue effects of rutin, a flavonoid extracted from the ethyl acetate extract of S. involucrata. Mice were subjected to a weight-loaded forced swim test (WFST) on alternate days for 3 wk. Rutin was administered orally to the mice for 7 days in dosages of 15, 30, and 60 mg/kg body weight, and several biomarkers of physical fatigue were evaluated: swimming time, c...

Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a major antiatherogenic factor in the blood vessel. Oxidative stress plays an important role in the pathogenesis of various cardiovascular diseases, including atherosclerosis. Decreased availability of endothelial NO promotes the progression of endothelial dysfunction and atherosclerosis. Rutin is a flavonoid with multi...

Background: DNA damage is one of the major consequences of radiation exposure onto the biological systems. A series of compounds including flavanoids were found to render DNA protection against radiation damage. In this study we elucidated the potential of rutin and rutin hydrate to protect plasmid DNA against damage induced by irradiation. Materials and Methods: DPPH and hydroxyl radical scave...

Rutin and naringenin, two phenolic compounds with antioxidant properties were encapsulated in lipid-based onion-type multilamellar vesicles (MLVs). After vesicles formation, the free, adsorbed/encapsulated analytes were well separated with size exclusion chromatography (SEC), and rutin and naringenin were quantified with UV-HPLC at 258 nm and 290 nm. A mathematical model was developed to separa...

This study aimed to investigate the incorporation of rutin into electrospun pullulan and poly(vinyl alcohol) (PVA) nanofibers to obtain ultraviolet (UV)-resistant properties. The effect of weight ratios between pullulan and PVA, and the addition of rutin on the nanofibers' morphology and diameters were studied and characterized by scanning electron microscopy (SEM). Fourier transform infrared (...

This paper reports the results of flavonoids determination expressed in rutin from marine algae. For this purpose, rutin and rutin AlCl3 complexes were spectrophotometrically studied in three domains of ligand concentrations: ligand Crut=1.34-6.7mg/L, 4-20mg/L and 2-32mg/L. The precision, accuracy, specificity, and the quantification limit of the method were verified. The calibration curve trac...

BACKGROUND Rutin is a polyphenolic natural flavonoid which possesses antioxidant and anticancer activity. In the present study the hepatoprotective effect of rutin was evaluated against carbon tetrachloride (CCl₄)-induced liver injuries in rats. METHODS AND MATERIALS 24 Sprague-Dawley male rats were equally divided into 4 groups for the assessment of hepatoprotective potential of rutin. Rats ...