نتایج جستجو برای: rvfv

تعداد نتایج: 294  

2018
Yuetao Li Yongkun Zhao Cuiling Wang Xuexing Zheng Hualei Wang Weiwei Gai Hongli Jin Feihu Yan Boning Qiu Yuwei Gao Nan Li Songtao Yang Xianzhu Xia

Rift Valley fever (RVF) is an acute, febrile zoonotic disease that is caused by the RVF virus (RVFV). RVF is mainly prevalent on the Arabian Peninsula, the African continent, and several islands in the Indian Ocean near southeast Africa. RVFV has been classified by the World Organisation for Animal Health (OIE) as a category A pathogen. To avoid biological safety concerns associated with use of...

Journal: :Clinical and vaccine immunology : CVI 2010
Reuben K Soi Fred R Rurangirwa Travis C McGuire Paul M Rwambo James C DeMartini Timothy B Crawford

Rift Valley fever (RVF) is an epizootic viral disease of sheep that can be transmitted from sheep to humans, particularly by contact with aborted fetuses. A capripoxvirus (CPV) recombinant virus (rKS1/RVFV) was developed, which expressed the Rift Valley fever virus (RVFV) Gn and Gc glycoproteins. These expressed glycoproteins had the correct size and reacted with monoclonal antibodies (MAb) to ...

2013
Imadeldin E. Aradaib Bobbie R. Erickson Rehab M. Elageb Marina L. Khristova Serena A. Carroll Isam M. Elkhidir Mubarak E. Karsany AbdelRahim E. Karrar Mustafa I. Elbashir Stuart T. Nichol

To elucidate whether Rift Valley fever virus (RVFV) diversity in Sudan resulted from multiple introductions or from acquired changes over time from 1 introduction event, we generated complete genome sequences from RVFV strains detected during the 2007 and 2010 outbreaks. Phylogenetic analyses of small, medium, and large RNA segment sequences indicated several genetic RVFV variants were circulat...

2012
Jacquelyn M. Bales Diana S. Powell Laura M. Bethel Douglas S. Reed Amy L. Hartman

Humans infected with Rift Valley Fever Virus (RVFV) generally recover after a febrile illness; however, a proportion of patients progress to a more severe clinical outcome such as hemorrhagic fever or meningoencephalitis. RVFV is naturally transmitted to livestock and humans by mosquito bites, but it is also infectious through inhalational exposure, making it a potential bioterror weapon. To be...

2011
Céline Gommet Agnès Billecocq Grégory Jouvion Milena Hasan Tânia Zaverucha do Valle Laurent Guillemot Charlène Blanchet Nico van Rooijen Xavier Montagutelli Michèle Bouloy Jean-Jacques Panthier

BACKGROUND Rift Valley fever virus (RVFV) causes disease in livestock and humans. It can be transmitted by mosquitoes, inhalation or physical contact with the body fluids of infected animals. Severe clinical cases are characterized by acute hepatitis with hemorrhage, meningoencephalitis and/or retinitis. The dynamics of RVFV infection and the cell types infected in vivo are poorly understood. ...

2018
Sebastian Napp Veronique Chevalier Núria Busquets Paolo Calistri Jordi Casal Mohamed Attia Rehab Elbassal Heba Hosni Hatem Farrag Noura Hassan Rasha Tawfik Sohair Abd Elkader Shahin Bayomy

Rift Valley Fever (RVF) is a mosquito-borne zoonosis, which may cause significant losses for the livestock sector and have serious public health implications. Egypt has been repeatedly affected by RVF epidemics, mainly associated to the importation of animals from sub-Saharan countries, where the disease is endemic. The objective of our study was the improvement of the surveillance and control ...

Journal: :Clinical and vaccine immunology : CVI 2009
David H Holman Adam Penn-Nicholson Danher Wang Jan Woraratanadharm Mary-Katherine Harr Min Luo Ellen M Maher Michael R Holbrook John Y Dong

Rift Valley fever virus (RVFV) has been cited as a potential biological-weapon threat due to the serious and fatal disease it causes in humans and animals and the fact that this mosquito-borne virus can be lethal in an aerosolized form. Current human and veterinary vaccines against RVFV, however, are outdated, inefficient, and unsafe. We have incorporated the RVFV glycoprotein genes into a nonr...

Journal: :The American journal of tropical medicine and hygiene 2015
Samuel Muiruri Ephantus W Kabiru Eric M Muchiri Hassan Hussein Frederick Kagondu A Desirée LaBeaud Charles H King

Few studies have focused on Rift Valley fever virus (RVFV) transmission in less arid, transitional landscapes surrounding known high-risk regions. The objective of this study was to identify evidence of RVFV exposure in Bodhei Village in a forested area at the edge of the RVFV-epidemic Garissa region. In a household cluster-based survey conducted between epidemics in early 2006, 211 participant...

2010
Mary E. Piper Sonja R. Gerrard

Rift Valley fever virus (RVFV) is a human and livestock pathogen endemic to sub-Saharan Africa. We have developed a T7-dependent system for the efficient production of RVFV-like particles (RVF-VLPs) based on the virulent ZH-501 strain of RVFV. The RVF-VLPs are capable of performing a single round of infection, allowing for the study of viral replication, assembly, and infectivity. We demonstrat...

2015
Ashwini Benedict Neha Bansal Svetlana Senina Idris Hooper Lindsay Lundberg Cynthia de la Fuente Aarthi Narayanan Bradford Gutting Kylene Kehn-Hall

There are currently no FDA-approved therapeutics available to treat Rift Valley fever virus (RVFV) infection. In an effort to repurpose drugs for RVFV treatment, a library of FDA-approved drugs was screened to determine their ability to inhibit RVFV. Several drugs from varying compound classes, including inhibitors of growth factor receptors, microtubule assembly/disassembly, and DNA synthesis,...

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