The liver is the organ that metabolizes nutrients and xenobiotics, and it is susceptible to injury by various toxins and metabolites. Alcohol liver disease (ALD) is one of the most common liver diseases around the globe. Although numerous efforts have been undertaken to combat this global health burden, there is no therapeutic modality to date for patients with ALD. In this issue of JCMA, Liu e...

Medicinal plants have been used for decades for the treatment of different diseases. Solanum nigrum L is an important medicinal plant in many traditional health care systems. It has been used for the management of liver disorders, diabetes, infections, cancer, inflammations and peptic ulcer. In the present study, we screened the green unripe S. nigrum L fruits and leaves for their cytotoxic act...

Background. Snails' species are associated with transmission parasitic disease as intermediate host. Biological control stands to be a better alternative to the chemical controls aimed against snails. The search of herbal preparations that do not produce any adverse effects in the non-target organisms and are easily biodegradable remains a top research issue for scientists associated with alter...

Introduction: Solanum nigrum (S. nigrum) has been shown to be hepatoprotective by Ayurvedic physicians but has not been scientifically evaluated so far. So, the present study was undertaken to explore the hepatoprotective activity of S. nigrum against experimentally induced hepatotoxicity in albino rats. Aim of the study: To explore the hepatoprotective activity of S. nigrum. Materials and Meth...

Malignant melanoma (MM) is the most dangerous type of skin cancer, killing more than 1,100 people each year in Canada. Prognosis for late stage and recurrent MM is extremely poor due to insensitivity to chemotherapy drugs, and thus many patients seek complementary and alternative medicines. In this study, we examined four commonly used anticancer herbs in traditional Chinese medicine, Hedyotis ...

The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and free radical scavenging enzymes activities. Rats...

The polysaccharide fraction from Solanum nigrum Linne has been shown to have antitumor activity by enhancing the CD4+/CD8+ ratio of the T-lymphocyte subpopulation. In this study, we analyzed a polysaccharide extract of S. nigrum to determine its modulating effects on RAW 264.7 murine macrophage cells since macrophages play a key role in inducing both innate and adaptive immune responses. Crude ...

Gnagnan Solanum indicum L. The proximate composition includes crude fibre 8 wet.ABSTRACT Solanum nigrum black nightshade is widely used in ethnomedicine for its hepatoprotective, anti-proliferative, anti-inflammatory and anti-oxidative.Nanomaterials and Nanotechnology. Green Synthesis and Characterization of Biocompatible Gold Nanoparticles. Regular Paper.The fresh leaves of Solanum indicum sho...

Solanum nigrum was found to proliferate in sediments with high levels of metal pollution. The effect of Zn on plant growth and tissue metal accumulation was assessed. The response of the plant to the inoculation with four different isolates of arbuscular mycorrhizal fungi (AMF) (Glomus sp. BEG140, Glomus claroideum, Glomus mosseae and Glomus intraradices) was studied. While the isolates of AMF ...

Liv.52 syrup, an Ayurvedic liver-tonic and extract of Solanum nigrum (one of the constituents of Liv.52) were orally administered (0.125 ml/kg b wt./day which is equal to human dose) to weaning rats for 11 weeks. Liv.52 treated rats exhibited better growth during 3rd to 8th week than those administered extract of S. nigrum or controls, after which period the body weight in all the groups gradua...