Bifidobacteria are frequently used in probiotic food and dairy products. Bifidobacterium bifidum S17 is a promising probiotic candidate strain that displays strong adhesion to intestinal epithelial cells and elicits potent anti-inflammatory capacity both in vitro and in murine models of colitis. The recently sequenced genome of B. bifidum S17 has a size of about 2.2 Mb and encodes 1,782 predict...

The effects of at least some probiotics are restricted to live, metabolically active bacteria at their site of action. Colonization of and persistence in the gastrointestinal tract is thus contributing to the beneficial effects of these strains. In the present study, colonization of an anti-inflammatory Bifidobacterium bifidum strain was studied in C57BL/6J mice under germ-free (GF) and specifi...

s S17

Newly formed B lymphocytes are a population of rapidly renewed cells in the bone marrow of mammals and their steady state production presumably depends on a cascade of regulatory cells and cytokines. Although considerable information has been forthcoming about the role of interleukin-7 (IL-7) in potentiating pre-B-cell proliferation, few studies have addressed the possibility that multiple cyto...

TABLE OF CONTENTS I. Preface................................................................................................................................................................................... S1 II. Executive Summary.............................................................................................................................................................. S2 III...

We calculate several “size-like” B observables within the microscopic threecluster model and study their potential constraints on the zero-energy astrophysical S17(0) factor of the Be(p, γ)B reaction. We find within our threecluster model that a simultaneous reproduction of the experimental data for the B radius and quadrupole moment and of the B-Li Coulomb displacement energy implies S17(0) = ...

As upper airway stimulation (UAS) surgical implantation is a new procedure, the authors thought it would be instructive to describe a single-institution's experience with the inception of a UAS program. The description of our experience at the University of Pennsylvania may be useful for planning purposes when surgeons and sleep medicine physicians are considering program development. Laryngosc...

The production of B lymphocytes and myeloid cells occurs in the bone marrow in association with a supporting population of stromal cells. To determine whether these processes are dependent upon the same or different populations of stromal cells, stromal cell lines were generated from the adherent layer of a Dexter type long-term bone marrow culture. These cultures support myeloid cells and thei...

Bone marrow stromal cells appear to be key regulatory elements in hematopoiesis and lymphopoiesis. These stromal cells respond to cytokine exposure and alter their pattern of hematopoietic growth factor production, suggesting a degree of functional plasticity. We examined the effect of two cytokines, interleukin-1 (IL-1) and IL-4, on stromal cell regulation of pre-B cell generation using the bo...

S17(0), has now been measured with high precision (±5% or better) by different groups and good agreement is found, even when very different methods are employed. We review the decade long research program to measure the cross section of the Be(p, γ)B reaction using the Coulomb dissociation method, including the pioneering RIKEN1 experiment carried out during March 1992, followed by RIKEN2, GSI1...