????????????TKS?????????????????????????????????????????????????????????????SAD???????????????????????????????????????????????TKS?SAD?????????????????????????????????????????????BIS/BAS ?behavioral inhibition/activation system???????????????????????????????????????????????274???????????????????????????????BIS/BAS,???????????????????????????BIS/BAS?SAD????????????????????????TKS?????????????????...

Objective: There are well-established benefits of mindfulness in clinical settings, but the different roles of mindfulness facets in each disorder yet remain unclear. The purpose of the current study was to investigate between-group comparisons of the facets of mindfulness among patients with Major Depression Disorder (MDD), Social Anxiety Disorder (SAD) and healthy individuals. Methods: The p...

A gene unpaired during the meiotic homolog pairing stage in Neurospora generates a sequence-specific signal that silences the expression of all copies of that gene. This process is called Meiotic Silencing by Unpaired DNA (MSUD). Previously, we have shown that SAD-1, an RNA-directed RNA polymerase (RdRP), is required for MSUD. We isolated a second gene involved in this process, sad-2. Mutated S...

Social anxiety disorder (SAD) and antisocial personality disorder (ASPD) are not often thought of as being comorbid. However, recent research suggests the existence of a SAD subtype with characteristics atypical of SAD but common to ASPD. Thus, we explored two competing hypotheses: (1) SAD and ASPD represent opposite ends of a single dimension, or (2) SAD and ASPD exist on two separate dimensio...

BACKGROUND There is limited knowledge of the course of social anxiety disorder (SAD) from adolescence into adulthood, and how SAD and alcohol use disorder (AUD) symptoms change together over time. The current study examined how persistent and adolescent-limited SAD relate to alcohol symptom trajectories across adolescence and into adulthood, as well as gender differences in the course of SAD an...

objective: this study was conducted to investigate the effectiveness of education based of the cognitive, metacognitive, and behavioral model on the reduction of meta-worry beliefs in patients with social anxiety disorder (sad). methods: the research was a quasi-experimental study with pretest-posttest design and a control group. the statistical population comprised all patients with sad referr...

Causes of initiation and progression of sporadic Alzheimer's disease (sAD) are likely multiple and include impairment of mitochondrial bioenergetics. We analyzed RNA expression levels of multiple mitochondrial oxidative phosphorylation (OXPHOS) and biogenesis (mitobiogenesis) genes in unfixed hippocampal (WH) frozen sections (10 sAD; 9 CTL) and laser-captured hippocampal pyramidal neurons (PyNs...

Erythrocyte sickling on deoxygenation in vitro occurs in transgenic SAD mice, hemizygous for a modified human sickle hemoglobin, HbSAD [alpha 2 beta 2S(beta 6val)Antilles (beta 23 lle)D- Punjab (beta 121Gln)] (SAD-1, 19% HbSAD; beta-thal/SAD-1, 26% HbSAD). The present study examines the cellular defects in vivo and pathologic changes observed in SAD-1 mice at atmospheric oxygenation as well as ...