Background Non-enzymatic hydroxylation of aromatic compounds to the respective phenolic derivatives is a possible metabolic pathway of xenobiotics. The formed metabolites can undergo consecutive oxidative reactions with free radicals to form potential toxic molecules. Objective Development of HPLC methods to separate, identify and quantitate the main products formed from salicylic acid, 2,3-d...

Salicylic acid (SA) is an endogenous plant growth regulator, acting as non enzymatic antioxidant and has a regulatory effect on some physiological and biochemical processes. Therefore, this work was conducted during two successive summer seasons to evaluate the performance of two sunflower cultivars (Sakha 53 and Giza 102) to salicylic acid. The plants were grown at the experimental station of ...

The influence of addition 2,4,6,8, and 10 microM of benzoic and cinnamic acids and selected phenolic acids (salicylic, p-hydroxybenzoic, gentisic, protocatechuic, vanillic, syringic, o-coumaric, p-coumaric, caffeic, ferulic, sinapic) on the activity of pancreatic lipase was examined in vitro. The strongest inhibition activities were observed with caffeic, ferulic and benzoic acid, while sinapic...

Transmural potential difference (PD) was measured in vivo under continuous perfusion of the rat stomach. Lumina! NaF (5 mM) perfusion elicited a net temporal decrease of PD, whereas lower NaF concentrations (1 and 2 mM) had no effect. The fall of PD induced by 5 mM NaF was abolished at pH 8.4 and was enhanced (161%) at pH 3.2. Compared to NaF alone, the decrease of PD induced by the simultaneou...

Hepatotoxicity is one of the common side effects of nonsteroidal anti-inflammatory drugs (NSAIDs). We investigated the cytotoxicity of 18 acidic NSAIDs (3 salicylic acids, 3 anthranilic acids, 6 arylacetic acids, 6 arylpropionic acids) to freshly isolated rat hepatocytes as assessed by the NSAID-induced leakage of lactate dehydrogenase (LDH) in order to determine structural requirements for the...

Analysis of DRIFTS spectra was used for a quantitative study of competitive adsorption of myristic and salicylic acids onto kaolinite or gamma-alumina. Peaks unique to the ring or the chain were selected and single molecule studies used as calibration. Samples were exposed to hexane solution containing equal molecular quantities of each acid. The surface loading of salicylic acid was not influe...

the effects of different concentrations of salicylic acid as compared with control and as well with distilled water treatment were assessed on induction of resistance to chilling injury and quality of sweet lemon during its storage. for the purpose, sweet lemon fruits were treated by immersion method for 5 minutes in salicylic acid (200,400 and 600 mg/lit) and then packed in polyethylene bags t...