sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...

background: sarcoidosis is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. angiotensin-converting enzyme (ace) is a pathophysiologic marker of sarcoidosis. we present the ace insertion/deletion (i/d) polymorphism in correlation with serum ace level in iranian patients with sarcoidosis. methods: from jan 2014 to jan 2015, 102 iranian patients who h...

Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Case Presentation: A 48-years-old woman presented with inflammatory back p...

Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sa...

sarcoidosis is multi organ disease with cutaneous manifestation in 20%-35% patients. cutaneous sarcoidosis has variable manifestations that make it difficult to diagnose. so clinical, histopathologic and laboratory evaluation is needed for diagnosis. most of cutaneous lesions presents as nodul, maculopapule and plaque. morpheaform lesion is a rare presentation of cutaneous sarcoidosis. this cas...

  Sarcoidosis is a systemic disease that is characterized with noncaseating granulomatous nodules which present in multiple organs specially lungs (90%) . Incidence of masses due to Sarcoidosis in upper extremity is low and most cases present in association with involvement of pulmonary hilary lymph nodes. In this article we present a rare case of Sarcoidosis which presented as a single soft ti...

sarcoidosis is a chronic multisystem disorder of unknown etiology. all parts of the body can be affected but the organ most frequently affected is the lung. otolaryngologic manifestations occur in 20% to 40% of cases of sarcoidosis and the spectrum of lesions that may come under the purview of otolaryngologist is broad. in this case report a patient is presented with large cervical lymphadenopa...

we report a three-phase bone scintigraphy for the diagnosis of a peripheral bone lesion caused by systemic sarcoidosis. a 32-year-old man with suspected osteomyelitis of the right forefinger underwent three-phase bone scintigraphy with tc-99m hydroxymethylene diphosphonate (hmdp) and single-photon emission computed tomography/computed tomography (spect/ct). the lesion was rich in blood flow acc...