Objective(s): Schwann cells (SCs) have a wide range of applications as seed cells in the treatment of nerve injury during transplantation. However, there has been no report yet on kinds of proteomics changes that occur in Schwann cells before and after peripheral nerve injury.Materials and Methods: Activated Schwann cells (ASCs) and normal Schwann cells (NSCs) were obtained from adult Wistar ra...

a b s t r a c tintroduction: peripheral nerve injury is a common disorder and leads to permanent neurological defects. schwann cells have been shown to have nerve repair after being transplanted in peripheral nerve injury. the aim of this study was to determine the beneficial effect of allograft schwann cells on electrophysiological outcome after transection of the sciatic nerve in rats.methods...

Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...

spinal cord injury (sci) is a debilitating disease which leads to progressive functional damages. because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. different cellular and molecular approaches were investigated in sci animal models. cellular transplantation of stem cells can potentially replace damaged tissue and provid...

after central nervous system (cns) injuries, the regeneration process does not work out well except for remyelination process. this remyelination capacity in cns can be mentioned as a worthy example of stem/precursor cell-mediated renewal process. remyelination in cns is mediated by schwann cells which act mainly as remyelinating agents in peripheral nervous system (pns) but several studies hav...

treatment of spinal cord injury by exogenous cells has brought both successful and unsuccessful results. olfactory ensheathing cells and schwann cells have been widely used for transplantation purposes. in this study, we investigated the effects of these cells on contused spinal cord by introducing cells into subarachnoid space. fifty thousand schwann cells or olfactory ensheathing cells or a m...

background: adipose-derived stem cells (adscs) are a population of pluripotent cells used for tissue engineering purposes. the main purpose of the present study was to transdifferentiate the adscs to schwann-like cells and to determine the intensity of apoptosis in adscs during the transdifferentiation process.   methods: adscs were isolated from the inguinal adipose tissue of adult rats and th...

Melanocytes are derived from neural crest cells, which also differentiate into neurons, glial bone/cartilage and smooth muscles. Melanocyte-inducing transcription factor (MITF) promotes melanocyte development differentiation through activating pigment genes. Since MITF activates most of its target genes represses a few them, we aimed to characterize repressed by MITF. By using RNA sequencing ch...

Mycobacterium leprae, the pathogen that causes human leprosy, has a unique affinity for infecting and persisting inside Schwann cells, principal glia of peripheral nervous system. Several studies have focused on this intricate host-pathogen interaction as an attempt to advance current knowledge mechanisms governing nerve destruction disease progression. However, during chronic course leprosy ne...