OBJECTIVES/HYPOTHESIS The purpose of this study was to evaluate the Ras GTPase (Ras) to extracellular signal-regulated kinase (ERK) pathway in vestibular schwannoma (VS) cell cultures and patient excised schwannoma tumors. Mitogen-activated protein kinase kinase (MEK) inhibitor CI-1040 (PD184352) was utilized to evaluate the effect of specific MEK inhibition on benign schwannoma cell culture pr...

schwannoma is a solitary, slow growing,  benign tumour of the peripheral  nerve sheath, and it is most common locations are the head, neck, the flexor surfaces of the extremities, retroperitoneal and posterior mediastinium. external female genital organs are the least common location site of the schwannoma. only a few cases of vulvar schwannoma have been reported.we report 65 year- old woman pr...

  Ancient schwannomas rarely found in the central nervous system and ancient change in an intracranial schwannoma (intracranial portion of the trigeminal nerve) is extremely rare. A seventy-year man presented with headache of 3 months duration and one episode of generalized tonic-clonic seizures. Imaging findings were suggestive of left temporal high grade lesion. During surgery there was well...

Magnetic Resonance Imaging (MRI) has been the primary imaging modality and has revolutionized the imaging of brain tumors. MRI can display accurate multi planer imaging without interfering of adjacent structures specially for posterior fossa mass lesion. MRI is the imaging modality of choice for cerebollo-pontine (CP) angle Schwannoma. The study was performed to determine, the diagnostic accura...

Introduction: Presence of vestibular schwannoma and a simultaneous glomus jugulare tumor is an extremely rare event. There is only one case report regarding the incidence of a contralateral vestibular schwannoma, along with a glomus jugulare tumor. Herein, we present the second case with a contralateral tumor.   Case Report: A 69-year-old woman presented with a long hist...

Hybrid benign peripheral nerve sheath tumors are rare tumors exhibiting areas of more than one neural neoplasm such as schwannoma/neurofibroma, neurofibroma/perineurioma, or schwannoma/perineurioma. These tumors usually arise in the skin of the extremities and trunk, and less commonly affect extracutaneous sites. Here we report two cases of these tumors exhibiting hybrid features of schwannoma/...

Benign epithelioid schwannoma is a very rare variant of schwannoma, that can pose a diagnostic challenge. The reported cases were predominantly located in dermal/subcutaneous tissue. Although conventional schwannoma occurring in the posterior mediastinum was common, to our knowledge, no mediastinal benign epithelioid schwannoma was reported in English literature. Herein, we presented a case of ...

Schwannoma, also termed neurilemmoma, arises form Schwann cells, which cover the peripheral nerves. It commonly occurs in the peripheral nerve of the limbs or body, spinal cord, and the central nervous system. Occasionally, Schwannomas can occur elsewhere, including subcutaneous t issue, the re t roper i toneum, mediastinum, vulva, breast, larynx, and foot. There has been a relatively small num...

Plexiform schwannoma is an infrequent variant of schwannoma characterized grossly and microscopically by multi-nodular growth. Although plexiform schwannoma has such growth patterns, it is a benign tumor as well as a conventional schwannoma. It rarely infiltrates adjacent organs or arises from the organ itself. In this report, we describe a case in which plexiform schwannoma involved the trache...

INTRODUCTION Gastrointestinal stromal tumor (GIST) is the commonest mesenchymal tumor of GI tract and 60-70% of it seen in the stomach, whereas Gastric schwannoma is a benign, slow growing and one of the rare neoplasms of stomach. Age distribution, clinical, radiological features and gross appearance of both tumors are similar. PRESENTATION OF CASE We report a rare case of gastric schwannoma ...