Sciatica is characterized by pain and discomfort occurring frequently with impingement at the level of spinal nerve along the regions innervated by the sciatic nerve. Compression and irritation of the nerve often occurs with a spinal cause such as lumbar disc hernia or spinal stenosis. Compression of the nerve by an arteriovenous malformation is very rare among the causes leading to non-discoge...

background and objective: sciatic nerve transection is characterized by a rapid wave of motoneuron death associated with progressive synaptic lesions. the purpose of this study was to evaluate the long term synaptic changes. materials and methods: this basic study was carried out on paraffin- or resin-embedded tissue blocks for evaluation of synaptophysin and choline acetyl transaferase (chat) ...

introduction: repair of peripheral nerve injuries is an intensive area of challenge and research in modern reconstructive microsurgery. intensive research is being carried out to develop effective alternatives to the standard nerve autografting, avoiding its drawbacks. the aim of the study was to evaluate the effectiveness of a newly designed mechanical device for the reconstruction of the scia...

objective: to assess the effect of heparin binding neurotrophic factor (hbnf) on sciatic nerve regeneration in animal model of rat. methods: seventy-five male wistar rats were divided into five experimental groups randomly (each group containing 15 animals): sham operation group (sham), autograft group (auto), transected control (tc), chitosan conduit (chit) and heparin binding neurotrophic fac...

the nervous system has an important and vital role in the human body, but unfortunately the repairment of damaged nervous tissue is very slowly. for a long time, the scientists have been involved in finding ways to speed up this process. radiation of low power he-ne laser has been suggested to as a way to improve this issue. in this study, 20 rats were divided randomly into control and case gro...

objective (s): scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. this study evaluates the translational capacity of four of physical injury models to induce scar formation around the sciat...

background: initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. the purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves. methods: nmri mice (n = 200) with injured left paw, caused by crushing their sciatic nerves, were randomly sele...

to evaluate the effects of local administration of the fetal brain extract (fbe) on the crushed peripheral nerve, 15 male wistar rats were used. the right sciatic nerve of 10 rats was locally underwent the tense compression for 30 seconds and then randomly divided into experimental and control (sham) groups. the remained rats were considered as intact animals. treatment was commenced weekly, by...