The carmine spider mite Tetranychus cinnabarinus is a major pest of crop and vegetable plants worldwide. Previous studies have shown that scopoletin is a promising acaricidal compound against Tetranychus cinnabarinus. However, the acaricidal mechanism of scopoletin remains unclear. In the present study, 12 full-length cDNAs of chitinase (CHIT) genes from Tetranychus cinnabarinus (designated TcC...

A comparative study of the in vitro effects of the coumarin compounds, scopoletin and aflatoxin B1 (AFB1), on bovine (Bos indicus) hepatic mitochondrial respiration was carried out polarographically, using isocitrate -NAD+ (3 - site), succinate (2 - site), and reduced cytochrome c (1 - site), as respiratory substrates. Both scopoletin and AFB1 elicited a substrate--dependent stimulation or inhi...

The carmine spider mite, Tetranychus cinnabarinus (Boisduval), is an economically important agricultural pest that is difficult to prevent and control. Scopoletin is a botanical coumarin derivative that targets Ca2+-ATPase to exert a strong acaricidal effect on carmine spider mites. In this study, the full-length cDNA sequence of a plasma membrane Ca2+-ATPase 1 gene (TcPMCA1) was cloned. The se...

Hypertriglyceridemia is an independent risk factor of cardiovascular diseases. It is caused by the imbalance between hepatic triglyceride production and peripheral removal. Lipoprotein lipase (LPL) plays a central role in the removal of plasma triglyceride. During the screening of possible anti-dyslipidemic drugs, we observed that scopoletin (6-methoxy-7-hydroxycoumarin) significantly increased...

Plant coumarins are important components of the human diet and a number them considered to possess chemopreventive therapeutic properties against cancer. Scopoletin, natural coumarin component has been shown inhibit growth many cancer cells. In this study, cytotoxic activity scopoletin was studied neuroblastoma cells SHSY5Y. The evaluated by Sulphorhodamine B (SRB) assay xCELLigence system. It ...

Drug resistance and the severe side effects of chemotherapy necessitate the development of novel anticancer drugs. Natural products are a valuable source for drug development. Scopoletin is a coumarin compound, which can be found in several Artemisia species and other plant genera. Microarray-based RNA expression profiling of the NCI cell line panel showed that cellular response of scopoletin d...

Two to three days after harvesting, cassava (Manihot esculenta Crantz) roots suffer from post-harvest physiological deterioration (PPD) when secondary metabolites are accumulated. Amongst these are hydroxycoumarins (e.g. scopoletin and its glucoside scopolin) which play roles in plant defence and have pharmacological activities. Some steps in the biosynthesis of these molecules are still unknow...

Biosynthesis, Puberulin, C oum arins, Agathosma puberula Umbelliferone and scopoletin are well utilized as precursors o f puberulin , a 7-O-prenyl e ther o f isofraxidin elaborated by Agathosma puberula Fourc. (R utaceae). As ferulic, sinapic, and caffeic acids were all m ore poorly utilized than 4 '-hydroxycinnam ic (/?-coumaric) acid, the partial biosynthetic route: 4 '-hydroxycinnam ic acid ...

Previously, our laboratory provided evidence that lipoic acid (LA) covalently bonded to various antioxidants, resulted in enhanced neuroprotection compared to LA on its own. The naturally occurring compound scopoletin, a coumarin derivative, has been shown in various in vitro studies to have both antioxidant and anti-inflammatory mechanism of actions. The present investigation was designed to d...

"1 Sargent, J. A., and F. Skoog, "Effects of indoleacetic acid and kinetin on scopoletin-scopolin levels in relation to growth of tobacco tissue in vitro," Plant Physiol. (in press, 1960). 12 Goodwin, R. H., and C. Taves, "The effect of coumarin derivatives on the growth of Avena roots," Amer. J. Bot., 37, 224-231 (1950). 13 Avers, C., and R. H. Goodwin, "Studies on roots, IV. Effect of coumari...