BACKGROUND Concurrent infection with multiple pathogens is common in tropics, posing diagnostic and treatment challenges. Although co-infections of dengue, malaria, leptospirosis and typhoid in various combinations have been described, data on dengue and scrub typhus co-infection is distinctly limited. METHODOLOGY This study was a retrospective analysis of dengue and scrub typhus co-infection...

BACKGROUND The aetiological diagnostic of fevers in Laos remains difficult due to limited laboratory diagnostic facilities. However, it has recently become apparent that both scrub and murine typhus are common causes of previous undiagnosed fever. Epidemiological data suggests that scrub typhus would be more common in rural areas and murine typhus in urban areas, but there is very little recent...

BACKGROUND Scrub typhus, a potentially fatal rickettsial infection, is common in Asia. Although serologic surveys suggested that as many as one-fourth of cases of scrub typhus might be in children, very few reports of childhood scrub typhus are available in the medical literature. OBJECTIVES To document the clinical, laboratory and epidemiologic characteristics of pediatric patients with scru...

BACKGROUND Scrub typhus has been increasingly reported in Southern China, and public health authorities are concerned about its increased incidence. Additionally, little evidence is available on the epidemiology of scrub typhus in Southern China. This study aims to analyze the epidemiological and geographic features of ST in Guangzhou City, Southern China, to guide the future prevention efforts...

Scrub typhus is a potentially fatal mite-borne febrile illness, primarily of the Asia-Pacific Rim. With an endemic area greater than 13 million km2 and millions of people at risk, scrub typhus remains an underreported, often misdiagnosed febrile illness. A comprehensive, updatable map of the true distribution of cases has been lacking, and therefore the true risk of disease within the very larg...

Scrub typhus is transmitted by the larval stage of trombiculid mites. Environmental factors, including land cover and land use, are known to influence breeding and survival of trombiculid mites and, thus, also the spatial heterogeneity of scrub typhus risk. Here, a spatially autoregressive modelling framework was applied to scrub typhus incidence data from Taiwan, covering the period 2003 to 20...

Scrub typhus is an important tropical infection. The pathogenic organism is Rickettsia tsutsugamushi which can be transmitted to humans by the bite of larval-stage trombuculid mites or chiggers. This disease can cause acute febrile illness. The pleuropulmonary manifestation of scrub typhus can be seen although it is not common. Here, the author reviewed and summarized the characteristics of rep...

A microtiter enzyme-linked immunosorbent assay (ELISA) has been developed for the titration of antibodies against scrub typhus in human and animal sera. Scrub typhus rickettsiae were grown in monolayers of irradiated mouse LM3 cells and separated from host cell materials by differential centrifugation, filtration through a glass filter (AP-20, Millipore Corp.), and isopycnic banding in Renograf...

Scrub typhus is a reemerging rickettsial infection caused by Orientia tsutsugamushi transmitted through the bite of larval forms of a trombiculid mite. The clinical presentation of scrub typhus mimics other acute febrile illnesses thus making it difficult to diagnose clinically. The present work is a retrospective study of clinico laboratory profile of seropositive cases of scrub typhus present...

OBJECTIVES We aimed to evaluate the relationships between climate variability, animal reservoirs and scrub typhus incidence in Southern China. METHODS We obtained data on scrub typhus cases in Guangzhou every month from 2006 to 2014 from the Chinese communicable disease network. Time-series Poisson regression models and distributed lag nonlinear models (DLNM) were used to evaluate the relatio...