Background: The aim of this study was to evaluate whether secreted frizzled-related protein 4 (sFRP4), 5 (sFRP5), and chemerin serum concentrations in early pregnancy are associated with the development gestational diabetes mellitus (GDM) an obese cohort. In previous studies, increased sFRP4 chemerin, decreased sFRP5 were GDM normal overweight women. Methods: exploratory case control study, sFR...

objective: the role of wnt signaling and its antagonist; secreted frizzled related protein type 4 (sfpr4) was reported in rodent ovarian follicular development. this study examines immunolocalization of sfrp4 in ovaries of polycystic ovary (pco) rat model and evaluates its role in follicular growth arrest and its premature differentiation. materials and mathods: pco was induced with daily admin...

Abnormal inactivation of the Wnt/β-catenin signaling pathway is involved in skin diseases like androgenetic alopecia, vitiligo and canities, but small-molecule activators are rarely described. In this study, we investigated stimulatory effects escin on canonical cultured human dermal papilla cells (hDPCs). Escin stimulated signaling, resulting increased β-catenin lymphoid enhancer-binding facto...