Amorphous alumino phosphate (AP) and zirconium phosphate (ZP) materials possessing an ordered nanoporosity have been successfully synthesized by a hydrothermal method using a P123 block co-polymer as the structure directing agent. The materials exhibited excellent catalytic activity towards selective alkylation of phenol with cyclohexanol, where AP showed as high as 100% selectivity to produce ...

Quercetin, a ubiquitous flavonol, represents a promising leading drug for development of new chemotherapeutic agents. However, its limited cytotoxicity to cancer cells hampers its clinical use. In order to obtain novel quercetin derivatives with superior cytotoxicity, seven alkylated quercetin derivatives were synthesized. Solubility of these derivatives was determined by turbidimetry. Cytotoxi...

β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.

The research reported here demonstrates covalent binding to the metal-binding protein metallothionein (MT) by the therapeutic nitrogen mustard mechlorethamine. The most surprising aspect of this interaction is the selectivity of the alkylating agent for specific residues of MT. A combination of MS and proteolytic and enzymatic methods was used to deduce specific locations of mechlorethamine alk...

Major increases of the selectivity and/or reactivity in aminosugar and sugar O-alkylation were observed in the presence of tetrabutylammonium fluoride (TBAF) in comparison to TBAI under phase-transfer conditions or in solution. The presence of TBAF allowed the selective and rapid alkylation of the 6hydroxyl function of neamine and efficient preparation of protected intermediates useful in synth...

In this issue of Chem Catalysis, Koenigs and co-workers report an efficient photocatalytic system for activated C(sp3)−H bond functionalization at room temperature. This approach, based on visible-light-induced ruthenium catalysis, allows selective αC−H alkylation amides under mild reaction conditions.

A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated solvothermal treatment KH at 100 °C to generate deprotonated anionic species, which undergo selective C-alkylation arylalkenes 0 ambient temperature afford as major product.

[structure: see text] The asymmetric total synthesis of (-)-callystatin A has been achieved. The key steps generating the stereogenic centers rely on the asymmetric alpha-alkylation of aldehydes or ketones exploiting the SAMP/RAMP hydrazone alkylation methodology, as well as an enzymatic enantioselective reduction of a 3,5-dioxocarboxylate. For the construction of the alkene moieties, highly se...

The synthetic route in this work is based on the classical Friedel-Crafts strategy, and began with 1,4-dimethoxybenzene (I), followed by alkylation and selective demethylation of 2-methoxy function in 0x0-acid (3). The orthoformylation to synthesize aldehyde (6) was based on the Reimer-Tieman reaction. Chain extension of this aldehyde required methylation of the hydroxyl group and condensat...

Anisole is a straw-colored aromatic compound mainly used in making solvents, flavoring agents, perfumes, fuel additives, and the synthesis industries. Anisole, also known as methoxybenzene, synthesized from sodium phenoxide or phenol using various methylating agents. The use of dimethyl ether (DME) an alkylating agent seldom reported literature. Herein, we have anisole through O-alkylation proc...