Background: In the Biopharmaceutical Classification System (BCS), ibuprofen (IBU) belongs to Class II (poorly soluble, well-absorbed), which limits its therapeutic effectiveness due low bioavailability. Currently, self-microemulsifying drug delivery systems (SMEDDS) are used stabilize compounds and enhance solubility absorption of poorly soluble absorbable drugs. Therefore, objective this study...

Administration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipi...

Abstract
 The present investigation aimed to formulate a liquid self-microemulsifying drug delivery system (SMEDDS) of tacrolimus enhance its oral bioavailability by improving dispersibility and dissolution rate. Four SMEDDS were prepared using maisine CC as oil phase, labrasol ALF surfactant transcutol HP co-surfactant based on the solubility studies in these components. phase behavior co...