A field trial was conducted on several hundred farms in The Netherlands to compare the fertilizing capacity of boar spermatozoa stored for 1, 2, or 3 d at 18 C in either Kiev or Beltsville liquid extender (BL-1). Two storage volumes (25 and 100 ml) were used. Twelve Dutch Landrace boars, all in routine commercial artificial insemination service, provided the semen in twice-a-week collections. O...

AIM To assess the changes in semen parameters in men with spinal cord injury (SCI) and the possible causes of these changes. METHODS The study included 45 subjects with SCI. Semen retrieval was done by masturbation (2), vigorous prostatic massage (n = 13), penile vibratory stimulation (n = 13) or electroejaculation (n = 17). RESULTS The semen of men with SCI showed normal volume (2.3 +/- 1....

Bortezomib therapy has proven successful for the treatment of relapsed, relapsed/refractory, and newly diagnosed multiple myeloma (MM). At present, bortezomib is available as an intravenous injection, and its prolonged treatment is associated with toxicity and development of drug resistance. Here we show that the novel proteasome inhibitor ONX 0912, a tripeptide epoxyketone, inhibits growth and...

Bortezomib therapy has proven successful for the treatment of relapsed, relapsed/ refractory, and newly diagnosed multiple myeloma (MM). At present, bortezomib is available as an intravenous injection, and its prolonged treatment is associated with toxicity and development of drug resistance. Here we show that the novel proteasome inhibitor ONX 0912, a tripeptide epoxyketone, inhibits growth an...

OBJECTIVE Gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) are released from the pituitary gland and stimulate Leydig cells to produce testosterone and initiates spermatogenesis. Little is known about how and when the deterioration of semen quality occurs in patients with adult-onset gonadotropin insufficiency. DESIGN AND METHODS A retrospective study comprising...

Purpose: Carfilzomib is a selective, irreversible inhibitor of the chymotrypsin-like activity of the proteasome and is undergoing clinical evaluation in myeloma. ONX 0912 (oprozomib) is an orally bioavailable derivative. The activities of carfilzomib and ONX 0912 against solid tumor malignancies are lesswell understood.We investigated the impact andmechanisms of action of carfilzomib andONX0912...

OBJECTIVE To study the contribution of smoking and alcohol consumption to semen quality. DESIGN Retrospective analysis. SETTING University-based fertility clinic. PATIENTS AND METHODS Smoking and alcohol consumption were investigated in a control group (68) and in a group of 47 subjects with defined poor semen quality (PSQ). The control group was composed of subjects whose semen showed a ...

Collection frequencies and certain characteristics of Peregrine Falcon (Falco peregrinus) semen were investigated using semen from a falcon trained to copulate on a specially designed hat. Semen volume increased significantly when collections were increased from two to three times/day, but cells/ejaculate decreased. No significant difference in number cells/ejaculate or cells/microliter was det...

We aimed to determine the impact of metabolic syndrome (MetS) on reproductive function in men with secondary infertility, a condition that has received relatively little attention from researchers. Complete demographic, clinical, and laboratory data from 167 consecutive secondary infertile men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI; ...

and normal morphology. Curiously, some previous studies have also focused on elucidating the relationship between HPV-infection with sperm function and male infertility. Whereas, the inconsistent results they obtained made the issue controversial. For instance, in 1997, Lai et al. 5 found the incidence of asthenozoospermia among patients infected with either HPV-16 or HPV-18 was significantly h...