background: sepsis related-multiple organ dysfunction is associated with ileum injury. we aimed to determine the causes of ileal injury in two models of microbial sepsis resulted from infection with aeromonas hydrophila or its endotoxin. we also evaluated the protective effect of phytic acid .   methods: thin sections of ileum from 60 swiss male mice in control, bacteria-infected or lipopolysac...

Sepsis is a life-threatening organ dysfunction caused by disturbed response to infection. The development of sepsis preceded Systemic Inflammatory Response Syndrome (SIRS), which the overall inflammatory body severe lesion. role opportunistic pathogens in CER and may be considered proven, but value intestinal microbiome remains underestimated. survey systematized data on cell wall or membrane c...

Highlights:1. Bacteria remain a major cause of bacterial sepsis.2. The most common causal agent in septicaemia was the gram-positive bacterium. Abstract: Background: primary sepsis. Gram-negative bacteria are commonly isolated from sepsis patients. However, infections have also increased recently. Objective: To identify pattern infection patients Internal Medicine inpatient ward Dr. Soetomo Gen...

OBJECTIVE To identify the pathogens responsible for neonatal sepsis in a high-volume women and children's hospital in Southwest China. METHODS We retrospectively studied 133 neonates who were admitted to the West China Women and Children's Hospital between 2008 and 2012 for sepsis. The clinical characteristics of the patients were recorded, and the antibiotic sensitivities of the isolated bac...

In sepsis and multiple organ dysfunction syndrome (MODS) caused by gram-negative bacteria, lipopolysaccharide (LPS) initiates the early signaling events leading to the deleterious inflammatory response. However, it has become clear that LPS can not reproduce all of the clinical features of sepsis, which emphasize the roles of other contributing factors. Gram-positive bacteria, which lack LPS, a...

Sepsis is a severe medical condition and a leading cause of hospital mortality. Prompt diagnosis and early treatment has a significant, positive impact on patient outcome. However, sepsis is not always easy to diagnose, especially in critically ill patients. Here, we present a conceptionally new approach for the rapid diagnostic differentiation of sepsis from non-septic intensive care unit pati...

The clinical impact of β-lactamase has become a public health problem around the world in terms increased morbidity and mortality, especially child population. This study was aimed at determining bacteriological profile detection producing bacteria isolated from blood samples neonates. For this study, total 1335 neonates admitted NICU, SCBU, sepsis-suspected visiting Paropakar Maternity Women’s...

We performed a prospective study to evaluate the abilities of inflammatory cytokines to rule out the potential risk of sepsis and intracranial infection and to estimate the function of inflammatory cytokines in discriminating Gram-negative bacteria from Gram-positive ones through ROC analysis. During the course of the study, Levels of serum inflammatory cytokines were measured by flow cytometry...

Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical ...

Severe sepsis results in high morbidity and mortality. Immunomodulation strategies could be an adjunctive therapy to treat sepsis. Endotoxin is a component of gram-negative bacteria and plays an important role in the pathogenesis of septic shock when it is recognized by immune cells. Removal of endotoxin could be an effective adjunctive approach to the management of sepsis. Devices to adsorb en...